Phospholinked dye analogs with an amino acid linker

US9499862B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9499862-B2
Application numberUS-201514667869-A
CountryUS
Kind codeB2
Filing dateMar 25, 2015
Priority dateAug 25, 2010
Publication dateNov 22, 2016
Grant dateNov 22, 2016

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Abstract

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In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.

First claim

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What is claimed is: 1. A fluorescent dye having the formula: wherein R l is a fluorescent dye moiety; (AA) n is an amino acid linker; n is a selected from the integers 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12, and when n is two or greater, each n amino acid is independently selected; X is a polyvalent moiety, comprising a moiety having…

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What does patent US9499862B2 cover?
In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cy…
Who is the assignee on this patent?
Pacific Biosciences California Inc
What technology area does this patent fall under?
Primary CPC classification C12Q1/6869. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Nov 22 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).