One-component bone cement pastes and methods for curing them

Patent metadata

Field	Value
Publication number	US-9387275-B2
Application number	US-25522408-A
Country	US
Kind code	B2
Filing date	Oct 21, 2008
Priority date	Oct 22, 2007
Publication date	Jul 12, 2016
Grant date	Jul 12, 2016

Abstract

One-component bone cement pastes, containing:
AI at least one methacrylate monomer suitable for radical polymerization;
AII at least one polymer that is soluble in AI;
AIII at least one particulate polymer that is insoluble in AI and has a particle size of less than 500 μm;
optionally AIV at least one radical-forming initiator or at least one radical initiator that is soluble in AI and subject to thermal decomposition;
optionally AV at least one electrically conductive radio-opaquer, in the form of ferromagnetic particles.

First claim

The invention claimed is:

1. A one-component polymethylmethacrylate bone cement paste consisting of
(i) at least one methacrylate monomer selected from the group consisting of butan-1,3-diol-dimethacrylate, butan-1,4-diol-dimethacrylate, and hexan-1,6-diol-dimethacrylate;
(ii) at least one polymer that is soluble in the methacrylate monomer;
(iii) at least one particulate polymer selected from the group consisting of cross-linked poly-methylmethacrylate and cross-linked poly-methylmethacrylate-co-methylacrylate, wherein the particulate polymer is insoluble in the methacrylate monomer and having a particle size of less than 500 μm;
(iv) at least one radical initiator that is soluble in the methacrylate monomer and subject to thermal decomposition;

(v) at least one electrically conductive radio-opaquer;
(vi) optionally at least one additional radio-opaquer;
(vii) optionally at least one pharmaceutical agent; and
(viii) optionally at least one biocompatible elastomer that is particulate or soluble in the methacrylate monomer/methacrylate monomers;
wherein the ratio of said at least one methacrylate monomer to soluble polymer to particulate insoluble polymer to radical initiator to electrically conductive radio-opaquer is 25-50:2-35:40-70:0.5-4.0:2.0-20 based on the weight of the paste.

2. Bone cement paste according to claim 1 , wherein said at least one radical initiator that is soluble in the methacrylate monomer and subject to thermal decomposition can be activated.

3. Bone cement paste according to claim 1 , wherein said electrically conductive radio-opaquer is present and are particles having a particle size of 0.5 to 500 μm of cobalt, iron, NdFeB, SmCo, cobalt-chromium steel, zirconium, hafnium, titanium, titanium-aluminum-silicon alloys, or titanium-niobium alloys.

4. Bone cement paste according to claim 3 , wherein said electrical conductive radio-opaquer is iron in the form of ferromagnetic particles.

5. Bone cement paste according to claim 1 , wherein the methacrylate monomer is suited for distillation.

6. Bone cement paste according to claim 1 , wherein the soluble polymer is a poly-methylmethacrylate-co-polymer.

7. Bone cement paste according to claim 6 , wherein the soluble polymer is poly-methylmethacrylate-co-methylacrylate or poly-methyl methacrylate-co-styrene.

8. Bone cement paste according to claim 1 , wherein said at least one additional radio-opaquer is present and is selected from the group consisting of zirconium dioxide, barium sulfate, tantalum, and biocompatible calcium salts.

9. Bone cement paste according to claim 1 , wherein said at least one pharmaceutical agent is present and is selected from the group consisting of antibiotics, hormones, growth factors, and antiphlogistics.

10. Bone cement paste according to claim 1 , wherein said at least one biocompatible elastomer that is particulate or soluble in the methacrylate monomer is present.

11. Bone cement paste according to claim 10 , wherein said biocompatible elastomer is polybutadiene or poly-butadiene-co-styrene.

12. Method for curing a bone cement paste comprising exposing a bone cement paste according to claim 1 to an alternating magnetic field with a frequency in the range of 500 Hz to 50 kHz.

13. Method for curing a bone cement paste comprising heating a bone cement paste according to claim 2 by induction until the decomposition of the initiator commences.

Assignees

• Vogt Sebastian
• Buchner Hubert
• Heraeus Medical Gmbh

Inventors

• Vogt Sebastian
• Buchner Hubert

Classifications

• A61L24/0094 Primary

  containing macromolecular fillers · CPC title

• C08L33/10

  Homopolymers or copolymers of methacrylic acid esters · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title

• A61L24/0089

  containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084 · CPC title