Microchemical analysis device, a micro mixing device, and a microchemical analysis system comprising the same

Patent metadata

Field	Value
Publication number	US-9327255-B2
Application number	US-94633907-A
Country	US
Kind code	B2
Filing date	Nov 28, 2007
Priority date	Nov 29, 2006
Publication date	May 3, 2016
Grant date	May 3, 2016

Abstract

By situating a mixing pot in a junction of a first solution and a second solution or after the junction in a channel to temporarily retain these solutions, and situating an analysis sensor downstream from the mixing pot to detect the result of reaction of the first solution and second solution, heterogeneous solutions are mixed so as to react within the channel, and chemical analysis of one of the solutions is performed. According to this system, before the solutions have fully flowed through the remainder of the channel following the junction, the solutions are mixed uniformly at once by the turbulent and vortex flow generated within the mixing pot.

First claim

What is claimed is:

1. A microchemical analysis system configured to mix heterogeneous solutions and make them react to thereby perform chemical analysis of one of the solutions, the microchemical analysis system comprising:
a channel configured to merge and deliver a first solution and a second solution;
a mixing pot that is interposed in a junction of the first solution and the second solution or in the channel after the junction, that bulges out from the channel to have a predetermined capacity, and that is configured to temporarily retain the first solution and the second solution to flow out a mixed solution which is formed by a mixture of the first solution and the second solution;
a mixing acceleration part configured to apply a stirring force to the first and the second solutions temporarily retained inside the mixing pot;
a monitoring part configured to monitor a degree of mixture of the first solution and the second solution within the mixing pot during an application of the stirring force;
a mixing controller programmed to cause the mixing acceleration part to apply a stirring force, which is increased as a level of inhomogeneity of color tone is higher during the application of the stirring force;
an analysis sensor configured to detect a result of reaction of the first solution and the second solution that flow out of the mixing pot; and
a processing part configured to convert a result of reaction outputted by the analysis sensor into a physical quantity indicative of a chemical property of the solution.

2. A microchemical analysis system according to claim 1 , wherein the mixing pot has a spherical shape.

3. A microchemical analysis system according to claim 1 , wherein the mixing pot has a cylindrical shape having a radial direction along an extension direction of the channel.

4. A microchemical analysis system according to claim 1 , wherein the mixing pot has a cylindrical shape having a radial direction orthogonal to an extension direction of the channel.

5. A microchemical analysis system according to claim 1 , wherein the mixing pot has a fan shape in which part of a circular arc shape bulges out from one face of the channel.

6. A microchemical analysis system according to claim 1 , wherein the mixing acceleration part includes a piezoelectric device that generates vibrational waves.

7. A microchemical analysis system according to claim 1 , wherein the mixing acceleration part includes an actuator coming in contact with the mixing pot to transform part of the mixing pot.

8. A microchemical analysis system according to claim 1 , wherein the mixing controller causes the mixing acceleration part to continue or stop application of a stirring force, in accordance with a result of monitoring by the monitoring part.

9. A microchemical analysis system according to claim 1 , wherein the monitoring part includes an image sensor obtaining a projection image of the inside of the mixing pot, and outputs the projection image of the mixing pot as a result of monitoring.

10. A microchemical analysis system according to claim 1 , wherein:
the monitoring part includes an image sensor obtaining a projection image of the inside of the mixing pot, and outputs the projection image of the mixing pot as a result of monitoring; and
the mixing controller, based on the projection image, stops application of a stirring force when inhomogeneity of color tone within the mixing pot is less than a predetermined degree, and continues application of a stirring force when inhomogeneity of color tone within the mixing pot is equal to or more than a predetermined degree.

11. A microchemical analysis system according to claim 1 , wherein:
the monitoring part includes an image sensor obtaining a projection image of the inside of the mixing pot, and outputs the projection image of the mixing pot as a result of monitoring; and
the mixing controller, based on the projection image, applies a stirring force proportional to a degree of inhomogeneity of color tone within the mixing pot.

12. A microchemical analysis system according to claim 1 , wherein the mixing pot includes an outer shell that divides an outside of the mixing pot from an inside of the mixing pot,
wherein a portion of the outer shell of the mixing pot is formed of an elastic membrane, and
wherein the mixing acceleration part contacts the elastic membrane to apply the stirring force to the first and second solutions.

13. A microchemical analysis system according to claim 12 , wherein the elastic membrane is configured to be flexed by the mixing acceleration part so as to extend to the inside of the mixing pot to apply the stirring force to the first and second solutions.

14. A micro mixing device configured to mix heterogeneous solutions, the micro mixing device comprising:
a channel configured to merge and deliver a first solution and a second solution;
a mixing pot that is interposed in a junction of the first solution and the second solution or in the channel after the junction, that bulges out from the channel to have a predetermined capacity, and that is configured to temporarily retain the first solution and the second solution to flow out a mixed solution which is formed by a mixture of the first solution and the second solution;
a mixing acceleration part configured to apply a stirring force to the first and the second solutions temporarily retained inside the mixing pot;
a monitoring part configured to monitor a degree of mixture of the first solution and the second solution within the mixing pot during an application of the stirring force; and
a mixing controller programmed to cause the mixing acceleration part to apply a stirring force, which is increased as a level of inhomogeneity of color tone is higher during the application of the stirring force based on a result of monitoring by the monitoring part.

15. A microchemical analysis device, wherein
the microchemical device is connected to a micro mixing device comprising a channel configured to merge and deliver a first solution and a second solution and a mixing pot that is interposed in a junction of the first solution and the second solution or in the channel after the junction, that bulges out from the channel to have a predetermined capacity, and that is configured to temporarily retain the first solution and the second solution to flow out a mixed solution which is formed by a mixture of the first solution and the second solution, and which analyzes a chemical property of one of the solutions from a result of reaction of these solutions that flow out of the mixing pot, the microchemical analysis device comprising:
a mixing acceleration part configured to apply a stirring force to the first and the second solutions temporarily retained inside the mixing pot;
a monitoring part configured to monitor a degree of mixture of the first solution and the second solution within the mixing pot during an application of the stirring force;
a mixing controller programmed to cause the mixing acceleration part to apply a stirring force, which is increased as a level of inhomogeneity of color tone is higher during the application of the stirring force based on a result of monitoring by the monitoring part; and
a processing part configured to convert the reaction result into a physical quantity indicative of chemical properties of the solution.

Assignees

• Ito Naoko
• Kanayama Shoichi
• Toshiba Kk
• Toshiba Medical Sys Corp

Inventors

• Ito Naoko
• Kanayama Shoichi

Classifications

• B01L2300/0816

  Cards, e.g. flat sample carriers usually with flow in two horizontal directions · CPC title

• B01F13/0064 Primary

  Operations & Transport · mapped topic

• B01L2200/04

  Exchange or ejection of cartridges, containers or reservoirs · CPC title

• B01F15/00207

  Operations & Transport · mapped topic

• B01F15/00214

  Operations & Transport · mapped topic