Methods and compositions for reducing the environmental impact of animal waste

Patent metadata

Field	Value
Publication number	US-9326535-B2
Application number	US-201314347705-A
Country	US
Kind code	B2
Filing date	Feb 7, 2013
Priority date	Feb 16, 2012
Publication date	May 3, 2016
Grant date	May 3, 2016

Abstract

Methods for reducing the environmental impact of animal waste are described. In particular embodiments, the methods comprise administering to an animal an enzyme, such as alkaline phosphatase, that is effective to reduce the amount of a detrimental compound, such as ammonia or phosphorous, that is present in or released from animal waste. Also provided is a method for increasing phosphorus digestion in an animal. Compositions suitable for use in such methods are also described.

First claim

We claim:

1. A method for reducing the environmental impact of animal waste, comprising orally administering to an animal a composition comprising an effective amount of an alkaline phosphatase of SEQ ID NO:1, or an alkaline phosphatase having at least 95% sequence identity to SEQ ID NO:1, wherein said alkaline phosphatase comprises serine at position 102 and reduces the amount of one or more detrimental compounds present in or released from animal waste, and one or more orally acceptable carriers, thereby reducing the environmental impact of animal waste.

2. The method of claim 1 wherein said detrimental compound is ammonia or phosphorus.

3. The method of claim 1 , wherein said animal is a young animal.

4. The method of claim 1 , wherein said animal is a chicken or turkey.

5. The method of claim 1 , wherein said animal is a swine or cow.

6. The method of claim 1 , wherein the alkaline phosphatase is administered during one or more of starter phase, grower phase, and/or finisher phase.

7. The method of claim 1 , wherein the alkaline phosphatase is formulated in an animal feed or an animal feed additive.

8. The method of claim 1 , wherein one or more additional active ingredients are administered to said animal.

9. A composition suitable for oral administration to an animal comprising an effective amount of an alkaline phosphatase of SEQ ID NO:1, or an alkaline phosphatase having at least 95% sequence identity to SEQ ID NO:1 wherein said alkaline phosphatase comprises serine at position 102 and reduces the amount of one or more detrimental compounds present in or released from animal waste, and one or more orally acceptable carriers.

10. The composition of claim 9 , wherein said detrimental compound is ammonia or phosphorous.

11. The composition of claim 9 , wherein said animal is a young animal.

12. The composition of claim 9 , wherein said animal is a chicken or turkey.

13. The composition of claim 9 , wherein said animal is a swine or a cow.

14. The composition of claim 9 , wherein the alkaline phosphatase is administered orally during one or more of starter phase, grower phase, and/or finisher phase.

15. The composition of claim 9 , wherein said alkaline phosphatase is formulated in an animal feed or in an animal feed additive.

16. The composition of claim 9 , wherein said composition further comprises one or more additional active ingredients.

17. A method for increasing phosphorus digestion in an animal, comprising orally administering to said animal a composition comprising an effective amount of an alkaline phosphatase of SEQ ID NO:1, or an alkaline phosphatase having at least 95% sequence identity to SEQ ID NO:1, wherein said alkaline phosphatase comprises serine at position 102, and one or more orally acceptable carriers, thereby increasing digestion of phosphorus by said animal.

18. The method of claim 17 , wherein said alkaline phosphatase is SEQ ID NO:1.

19. The method of claim 17 , wherein said animal is a young animal.

20. The method of claim 17 , wherein said animal is a chicken or turkey.

21. The method of claim 17 , wherein said animal is a swine or a cow.

22. The method of claim 17 , wherein said alkaline phosphatase is administered during one or more of starter phase, grower phase, and/or finisher phase.

23. The method of claim 17 , wherein said alkaline phosphatase is formulated in an animal feed or in an animal feed additive.

24. A method for reducing the amount of one or more detrimental compounds present in or released from animal waste, increasing animal feed conversion rate, increasing animal feed efficiency, and/or increasing animal growth rate, comprising orally administering to an animal an effective amount of the composition of claim 9 .

Assignees

• Lilly Co Eli

Inventors

• Anderson David M
• Podkovyrov Sergey
• Huang Yuefang
• Schuster Kurt
• Ferrel Jon Edward

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• A23K50/00

  Feeding-stuffs specially adapted for particular animals · CPC title

• A23K20/168 Primary

  Steroids · CPC title

• C12Y301/03001

  Alkaline phosphatase (3.1.3.1) · CPC title