Bubble reduction device, chromatography device, bubble reduction method, and bubble reduction program

Patent metadata

Field	Value
Publication number	US-9285347-B2
Application number	US-201313903191-A
Country	US
Kind code	B2
Filing date	May 28, 2013
Priority date	May 30, 2012
Publication date	Mar 15, 2016
Grant date	Mar 15, 2016

Abstract

A bubble reduction device, chromatography device, bubble reduction method and bubble reduction program capable of reducing bubbles in an eluent. Included are a liquid accommodation portion, a liquid supply apparatus, an air layer formation apparatus, a first channel and an evacuation portion. The liquid accommodation portion accommodates a liquid that is to elute an analysis component from a specimen adsorbed to an adsorption portion. The liquid supply apparatus, by operation of a rod pushing up and polling down, sucks and discharges the liquid through an aperture portion of a tube portion, the aperture portion being oriented upward. The air layer formation apparatus forms an air layer in the tube portion. The first channel connects the liquid supply apparatus with the liquid accommodation portion. The evacuation portion is connected to the first channel via a first switching valve and evacuates the air layer through the first channel.

First claim

What is claimed is:

1. A liquid chromatography device comprising:
a liquid accommodation portion that accommodates a liquid that is to elute an analysis component from a specimen adsorbed to an adsorption portion;
a liquid supply apparatus that, by operation of a rod pushing up or pulling down, sucks or discharges the liquid through an aperture portion of a tube portion, the aperture portion being oriented upward;
an air layer formation apparatus that forms an air layer in the tube portion;
a first channel that connects the liquid supply apparatus with the liquid accommodation portion;
a second channel that is connected to the first channel via a second switching valve, the second channel supplying the liquid discharged from the liquid supply apparatus to the adsorption portion;
an evacuation portion that is connected to the first channel via a first switching valve and that evacuates the air layer through the first channel;
an atmosphere release valve that is provided at at least one of the tube portion, the first channel or the second channel, and that introduces the air layer into the tube portion; and
an analyzer that analyzes the analysis component in the liquid passed through the adsorption portion.

2. The liquid chromatography device according to claim 1 , wherein the air layer formation apparatus includes an atmosphere release valve provided at the first channel, and
the air layer is introduced into the tube portion through the first channel by an operation of the rod pushing up or pulling down in a state in which the atmosphere release valve is open.

3. The liquid chromatography device according to claim 1 , wherein an upper portion inner wall of the tube portion tapers toward the aperture portion, and a distal end portion of the rod is formed in a shape similar to the shape of the upper portion inner wall.

4. A bubble reduction method comprising:
a liquid accommodation step to accommodate a liquid into a liquid accommodation portion that is to elute an analysis component from a specimen adsorbed to an adsorption portion,
a liquid supply step, which by pushing up or down a rod of the liquid supply apparatus, sucks or discharges the liquid from the liquid accommodation portion through an aperture portion of a tube portion, the aperture portion being oriented upward;
a step to supply liquid discharged from the liquid supply apparatus to the adsorption portion, through which a first channel that connects the liquid supply apparatus with the liquid accommodation portion and a second channel that is connected to the first channel via a second switching valve, the second channel supplying the liquid discharged from the liquid supply apparatus to the adsorption portion;
an air layer formation step of forming an air layer in the tube portion and taking bubbles in the liquid into the air layer;
an evacuation step of evacuating the air layer in the tube portion through an evacuation portion that is connected to the first channel via a first switching valve and evacuates the air layer through the first channel;
a step to release the atmosphere through an atmosphere release valve that is provided at at least one of the tube portion, the first channel or the second channel, and that introduces the air layer into the tube portion; and
an analyzing step to analyze using an analyzer that analyzes the analysis component in the liquid passed through the adsorption portion.

5. The bubble reduction method according to claim 4 , wherein the liquid suction step includes pulling down a rod at a speed faster than a maximum movement speed of the liquid.

Assignees

• Satake Seiji
• Kasai Tokuo
• Sezaki Akira
• Matsubara Takeshi
• Arkray Inc

Inventors

• Satake Seiji
• Kasai Tokuo
• Sezaki Akira
• Matsubara Takeshi

Classifications

• G01N30/06 Primary

  Preparation · CPC title

• G01N2030/322

  pulse dampers · CPC title

• B01L3/502723

  characterised by venting arrangements · CPC title

• B01D19/0036

  Flash degasification (the other groups take precedence) · CPC title

• G01N30/20

  using a sampling valve · CPC title