Antipathogenic surfaces having selenium nanoclusters

Patent metadata

Field	Value
Publication number	US-9259005-B2
Application number	US-201113809611-A
Country	US
Kind code	B2
Filing date	Jul 13, 2011
Priority date	Jul 13, 2010
Publication date	Feb 16, 2016
Grant date	Feb 16, 2016

Abstract

The present invention is directed to methods for inhibiting growth of pathogens and to substrates with selenium nanoparticles or selenium nanoclusters having antipathogenic properties.

First claim

What is claimed is:

1. A method of inhibiting growth of a microbial, bacterial, fungal or yeast pathogen comprising contacting the pathogen to elemental selenium nanoclusters and inhibiting growth of the pathogen.

2. The method of claim 1 wherein the pathogen is on a substrate.

3. The method of claim 2 wherein the substrate includes a metal, a polymer, a ceramic or composites thereof.

4. The method of claim 3 wherein the metal is titanium, aluminum, platinum, niobium, tantalum, tin, nickel, cobalt, chromium, molybdenum, stainless steel, nitinol, Ti6Al4V, SiN, CoCrMo, zinc, silver, gold or alloys thereof.

5. The method of claim 3 wherein the polymer is polycarbonate, polyethyleneimine, isoplast, polyvinyl chloride, silicone, polyurethane, polyether imide, polycaprolactone, poly-lactic-co-glycolic acid, poly-lactic acid, poly-glycolic acid, polyethylene, polyethylene glycol, polydimethylsiloxane, polyacrylamide, polypropylene, polystyrene, polyether ether ketone (PEEK), ultra high molecular weight polyethylene (UHMWPE), hydrogels, or composites thereof.

6. The method of claim 3 wherein the ceramic is alumina, titania, hydroxyapatite, silica, calcium phosphates, bone cements, metal oxides or composites therefore.

7. A method of increasing the antimicrobial, antibacterial, antifungal or anti-yeast properties of a substrate comprising depositing selenium nanoclusters onto a substrate by contacting the substrate with a selenium precursor and a reducing agent for a time sufficient to form selenium nanoclusters on a surface of the substrate.

8. The method of claim 7 wherein the substrate includes a metal, a polymer, a ceramic or composites thereof.

9. The method of claim 8 wherein the metal is titanium, aluminum, platinum, niobium, tantalum, tin, nickel, cobalt, chromium, molybdenum, stainless steel, nitinol, Ti6Al4V, SiN, CoCrMo, zinc, silver, gold or alloys thereof.

10. The method of claim 8 wherein the polymer is polycarbonate, polyethyleneimine, isoplast, polyvinyl chloride, silicone, polyurethane, polyether imide, polycaprolactone, poly-lactic-co-glycolic acid, poly-lactic acid, poly-glycolic acid, polyethylene, polyethylene glycol, polydimethylsiloxane, polyacrylamide, polypropylene, polystyrene, polyether ether ketone (PEEK), ultra high molecular weight polyethylene (UHMWPE), hydrogels, or composites thereof.

11. The method of claim 8 wherein the ceramic is alumina, titania, hydroxyapatite, silica, calcium phosphates, bone cements, metal oxides or composites therefore.

12. The method of claim 7 wherein the selenium precursor is sodium selenite or selenious acid.

13. The method of claim 7 wherein the reducing agent is glutathione, hydrazine, dextrose, ascorbic acid or sodium ascorbate.

14. A method of inhibiting growth of a microbial, bacterial, fungal or yeast pathogen on the surface of a substrate comprising providing the surface of the substrate with elemental selenium nanoclusters, contacting the surface with the pathogen and inhibiting growth of the pathogen on the surface.

15. A method of reducing a microbial, bacterial, fungal or yeast pathogen infection in an animal comprising inserting into the animal a substrate having a surface including elemental selenium nanoclusters, contacting the surface with a microbial, bacterial, fungal or yeast pathogen and inhibiting growth of the pathogen on the surface.

Assignees

• Webster Thomas J
• Tran Phong Anh
• Univ Brown

Inventors

• Webster Thomas J
• Tran Phong Anh

Classifications

• A61K33/04

  Sulfur, selenium or tellurium; Compounds thereof · CPC title

• A01N25/34

  Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group · CPC title

• A01N59/02 Primary

  Sulfur; Selenium; Tellurium; Compounds thereof · CPC title

• A01N2300/00

  Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48 · CPC title