Prevention and treatment of alzheimer'S disease through electromagnetic field exposure

Patent metadata

Field	Value
Publication number	US-9238149-B2
Application number	US-201113230415-A
Country	US
Kind code	B2
Filing date	Sep 12, 2011
Priority date	Mar 11, 2009
Publication date	Jan 19, 2016
Grant date	Jan 19, 2016

Abstract

The invention includes a method of treating and preventing a neurological disorder, such as Alzheimer's Disease, in a subject in need thereof by positioning an electromagnetic field emitting source proximal to the subject and exposing the subject to an electromagnetic field having a predetermined frequency for a predetermined absorption period. Preferably, each individual treatment (comprising exposure to the predetermined frequency for the predetermined absorption period) is continued at a predetermined schedule (preferably daily) for a predetermined treatment period.
The predetermined frequency, according to a preferred embodiment, is about 918 MHz with a specific absorption rate (SAR) of about 0.25 W/kg+/−2 dB. The predetermined absorption period of this preferred embodiment is about one hour. The treatment period is long-term, being greater than about 6 months and preferably between about 7 and 9 months.

First claim

What is claimed is:

1. A method of treating and preventing a symptom associated with Alzheimer's Disease in a subject, wherein said symptom is associated with amyloid deposit or cognitive ability, comprising:
positioning an electromagnetic field emitting source proximal to the subject;
exposing the subject to electromagnetic treatment by an electromagnetic field generated by a digital signal generator, said electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequency having a range of about 902 MHz to about 928 MHz;
continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period greater that about three (3) days; and
reversing or reducing cognitive impairment or amyloid aggregation in said subject, decreasing a rate of amyloid deposition, or enhancing cognitive performance in said subject based on said step of continuing exposure for greater than about three (3) days.

2. The method of claim 1 , wherein the predetermined frequency is about 918 MHz.

3. The method of claim 1 , wherein the electromagnetic field has a specific absorption rate of about 0.25 W/kg to about 1.6 W/kg.

4. The method of claim 1 , wherein the predetermined absorption period is about one hour twice daily.

5. The method of claim 1 , wherein the predetermined treatment period is greater than about 4 months.

6. The method of claim 1 , wherein the predetermined treatment period is between about 7 and 9 months.

7. The method of claim 1 , wherein an enhancement of said cognitive performance in said subject is indicated by an enhancement of working or short-term memory performance of said subject.

8. A method of treating and preventing an amyloid-related neurological disorder in a subject thereof, comprising:
positioning an electromagnetic field emitting source proximal to the subject;
exposing the subject to electromagnetic treatment by an electromagnetic field generated by a digital signal generator, said electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequency having a range of about 902 MHz to about 928 MHz;
continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period greater than about three (3) days; and
reversing or reducing cognitive impairment or amyloid aggregation in said subject, decreasing a rate of amyloid deposition, or enhancing cognitive performance in said subject based on said step of continuing exposure for greater than about three (3) days.

9. The method of claim 8 , wherein the predetermined frequency is about 918 MHz.

10. The method of claim 8 , wherein the electromagnetic field has a specific absorption rate of about 0.25 W/kg to about 1.6 W/kg.

11. The method of claim 8 , wherein the predetermined absorption period is about one hour twice daily.

12. The method of claim 8 , wherein the predetermined treatment period is greater than about 4 months.

13. The method of claim 8 , wherein the predetermined treatment period is between about 7 and 9 months.

14. The method of claim 8 , wherein an enhancement of said cognitive performance in said subject is indicated by an enhancement of working or short-term memory performance of said subject.

15. A method of enhancing cognitive function in a normal, cognitively unimpaired subject, comprising:
positioning an electromagnetic field emitting source proximal to the subject;
exposing the subject to electromagnetic treatment by an electromagnetic field generated by a digital signal generator, said electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequency having a range of about 902 MHz to about 928 MHz;
continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period; and
enhancing cognitive performance of said subject based on said step of continuing exposure for said predetermined treatment period, wherein said enhancing cognitive performance of said subject includes enhancing working memory performance of said subject.

16. The method of claim 15 , wherein the predetermined frequency is about 918 MHz.

17. The method of claim 15 , wherein the electromagnetic field has a specific absorption rate of about 0.25 W/kg to about 1.6 W/kg.

18. The method of claim 15 , wherein the predetermined absorption period is about one hour twice daily.

19. The method of claim 15 , wherein the predetermined treatment period is greater than about three (3) days.

20. The method of claim 15 , wherein the predetermined treatment period is greater than about four (4) months.

Assignees

• Arendash Gary W
• Cao Chuanhai
• Tan Jun
• Univ South Florida

Inventors

• Arendash Gary W
• Cao Chuanhai
• Tan Jun

Classifications

• A61N5/02 Primary

  using microwaves · CPC title

• A61N2/02

  using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) · CPC title

• A61N2/006

  for magnetic stimulation of nerve tissue · CPC title