Prevention and treatment of brain diseases and disorders related to abnormal protein aggregation through electromagnetic field treatment

Patent metadata

Field	Value
Publication number	US-2016106997-A1
Application number	US-201514976986-A
Country	US
Kind code	A1
Filing date	Dec 21, 2015
Priority date	Mar 11, 2009
Publication date	Apr 21, 2016
Grant date	—

Abstract

A method of treating and preventing a neurological disorder, such as Alzheimer's disease, in a subject in need thereof by positioning an electromagnetic field emitting source proximal to the subject and exposing the subject to an electromagnetic field having a predetermined frequency (preferably ≈300-3,000 MHz) for a predetermined absorption period (preferably greater than ≈3 days). Each individual treatment (comprising exposure to the predetermined frequency for the predetermined absorption period) is continued at a predetermined schedule for a predetermined treatment period. The EMF can have a specific absorption rate up to about 8 W/kg. The methodology enhances cognition in the subject and/or treats/prevents the underlying neurological disorder or a symptom thereof.

First claim

What is claimed is:

1 . A method of treating or preventing symptoms associated with Alzheimer's disease in a subject, wherein said symptoms are associated with β-amyloid deposit or cognitive ability, comprising:
positioning an electromagnetic field emitting source proximal to the subject;
exposing the subject to electromagnetic treatment by a digital electromagnetic field, said electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequency being within an ultra-high frequency (UHF) range of about 300 MHz to about 3,000 MHz;
continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period greater than about three (3) days; and
reversing or reducing cognitive impairment or β-amyloid aggregation in said subject; decreasing a rate of β-amyloid deposition, or enhancing cognitive performance in said subject based on said step of continuing exposure for greater than about three (3) days.

2 . The method of claim 1 , wherein the predetermined frequency is within a range of about 902 MHz to about 928 MHz.

3 . The method of claim 1 , wherein the electromagnetic field has a specific absorption rate up to about 8 W/kg.

4 . The method of claim 1 , wherein the predetermined absorption period is about one hour per treatment session, twice daily.

5 . The method of claim 1 , wherein the electromagnetic field is pulsed and unmodulated.

6 . The method of claim 1 , wherein an enhancement of said cognitive performance in said subject is indicated by an enhancement of working or short-term memory performance of said subject.

7 . A method of treating or preventing an amyloid-related neurological disorder in a subject thereof, comprising:
positioning an electromagnetic field emitting source proximal to the subject, exposing the subject to electromagnetic treatment by an electromagnetic field generated by a digital signal generator said electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequency having a range of about 902 MHz to about 928 MHz; continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period greater than about three (3) days; and reversing or reducing cognitive impairment or amyloid aggregation in said subject, decreasing a rate of amyloid deposition, or enhancing cognitive performance in said subject based on said step of continuing exposure for greater than about three (3) days.

8 . The method of claim 7 , wherein the predetermined frequency is within a range of about 902 MHz to about 928 MHz.

9 . The method of claim 7 , wherein the electromagnetic field has a specific absorption rate up to about 8 W/kg.

10 . The method of claim 7 , wherein the predetermined absorption period is about one hour per treatment session, twice daily.

11 . The method of claim 7 , wherein the electromagnetic field is pulsed and unmodulated.

12 . The method of claim 7 , wherein an enhancement of said cognitive performance in said subject is indicated by an enhancement of working or short-term memory performance of said subject.

13 . A method of treating or preventing a neurological disorder in a subject thereof, where the neurological disorder is characterized by abnormal protein aggregation in or around a brain of the subject, the method comprising:
positioning an electromagnetic field emitting source proximal to the subject; exposing the subject to electromagnetic treatment by a digital electromagnetic field, said electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequency being within an ultra-high frequency (UHF) range of about 300 MHz to about 3,000 MHz; continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period greater than about three (3) days; and reversing or reducing the abnormal protein aggregation in said subject or decreasing a rate of protein deposition based on said step of continuing exposure for greater than about three (3) days.

14 . The method of claim 13 , wherein the predetermined frequency is within a range of about 902 MHz to about 928 MHz.

15 . The method of claim 13 , wherein the electromagnetic field has a specific absorption rate up to about 8 W/kg.

16 . The method of claim 13 , wherein the predetermined absorption period is about one hour per treatment session, twice daily.

17 . The method of claim 13 , wherein the electromagnetic field is pulsed and unmodulated.

18 . A method of enhancing cognitive function in a subject that is cognitively unimpaired, comprising:
positioning an electromagnetic field emitting source proximal to the subject; exposing the subject to electromagnetic treatment by a digital electromagnetic field, said electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequency being within an ultra-high frequency (UHF) range of about 300 MHz to about 3,000 MHz; continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period greater than about three (3) days; and enhancing cognitive performance in said subject based on said step of continuing exposure for greater than about three (3) days.

19 . The method of claim 18 , wherein the predetermined frequency is within a range of about 902 MHz to about 928 MHz.

20 . The method of claim 18 , wherein the electromagnetic field has a specific absorption rate up to about 8 W/kg.

21 . The method of claim 18 , wherein the predetermined absorption period is about one hour per treatment session, twice daily.

22 . The method of claim 18 , wherein the electromagnetic field is pulsed and unmodulated.

23 . The method of claim 18 , wherein an enhancement of said cognitive performance in said subject is indicated by an enhancement of working or short-term memory performance of said subject.

24 . A method of treating or preventing Age-Associated Memory Impairment, comprising:
positioning an electromagnetic field emitting source proximal to the subject; exposing the subject to electromagnetic treatment by a digital electromagnetic field, said electromagnetic field having a predetermined frequency for a predetermined absorption period; said predetermined frequency being within an ultra-high frequency (UHF) range of about 300 MHz to about 3,000 MHz; continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period; and enhancing cognitive performance in said subject based on said step of continuing exposure for said predetermined treatment period, wherein said enhancing cognitive performance of said subject includes enhancing working or short-term memory performance of said subject.

25 . The method of claim 24 , wherein the predetermined frequency is within a range of about 902 MHz to about 928 MHz.

26 . The method of claim 24 , wherein the electromagnetic field has a specific absorption rate up to about 8 W/kg.

27 . The method of claim 24 , wherein the predetermined absorption period is about one hour per treatment session, twice daily.

28 . The method of claim 24 , wherein the electromagnetic field is pulsed and unmodulated.

Assignees

• Arendash Gary W
• Cao Chuanhai
• Tan Jun
• Univ South Florida

Inventors

• Arendash Gary W
• Cao Chuanhai
• Tan Jun

Classifications

• A61N5/02

  using microwaves · CPC title

• A61N2/02

  using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) · CPC title

• A61N2/006 Primary

  for magnetic stimulation of nerve tissue · CPC title