System layout for an automated system for sample preparation and analysis

Patent metadata

Field	Value
Publication number	US-9236236-B2
Application number	US-201414333724-A
Country	US
Kind code	B2
Filing date	Jul 17, 2014
Priority date	Oct 29, 2010
Publication date	Jan 12, 2016
Grant date	Jan 12, 2016

Abstract

A sample preparation and analysis system. The system includes a housing with a sample preparation station and a sample analysis station positioned within the housing. The sample analysis station is spaced away from the sample preparation station. A transport assembly is configured to move at least one sample within the housing and between the sample preparation station and the sample analysis station.

First claim

What is claimed is:

1. A sample preparation and analysis system, comprising:
a housing;
a sample preparation station comprising a centrifuge positioned within the housing;
a sample analysis station comprising a mass spectrometer positioned within the housing and interconnected in an automated manner with the sample preparation station; and
a transport assembly configured to move at least one sample within the housing in an automated manner between the sample preparation station and the sample analysis station,
wherein the mass spectrometer is contained within a sliding drawer within the housing in the lower portion of the system.

2. The sample preparation and analysis system of claim 1 , wherein the sample preparation station is positioned substantially on one side of the housing, at a height that is greater than a height of a base of an analyzer included in the sample analysis station; and
the analyzer is positioned substantially on the other side of the housing, at a height that is less than a height of a base of the sample preparation station.

3. The sample preparation and analysis system of claim 1 , wherein the sample analysis station further includes one or more liquid chromatography pumps and at least one liquid chromatography mobile phase container, the at least one liquid chromatography mobile phase container being positioned at a height that is greater than a height of the one or more liquid chromatography pumps.

4. The sample preparation and analysis system of claim 1 , wherein the sample analysis station further includes an analyzer selected from the group consisting of a liquid chromatograph directly coupled to the mass spectrometer, a gas chromatograph directly coupled to the mass spectrometer, a surface desorption/ionizer directly coupled to the mass spectrometer, a liquid chromatography ultra-violet spectrometer, and a fluorescence spectrometer.

5. The sample preparation and analysis system of claim 1 , wherein the sample preparation station includes at least one of a specimen dock having one or more specimen racks capable of holding a specimen container and a reagent station having one or more reagent racks capable of holding one or more reagent containers.

6. The sample preparation and analysis system of claim 1 , further comprising a user interface, wherein the user interface is located centrally along the overall length of the housing between a left-hand sidewall of the housing and a right-hand sidewall of the housing.

7. The sample preparation and analysis system of claim 1 , wherein the transport assembly is configured to move the sample in at least one of an x-y direction, an x-y-z direction, or a rotary direction.

8. The sample preparation and analysis system of claim 1 , wherein the transport assembly includes a sample pipette assembly.

9. The sample preparation and analysis system of claim 1 further comprising a secondary processing station that includes one or more of a mixing station, an incubation station, and a matrix interference removal station and wherein the transport assembly is configured to move the at least one sample between the sample preparation station, the secondary processing station, and the sample analysis station.

10. The sample preparation and analysis system of claim 1 further comprising an injector station positioned in the housing, wherein the injection station is configured to receive a sample prepared from the transport assembly and transfer an aliquot of the sample to the sample analysis station.

11. A sample preparation and analysis system, comprising:
a housing;
a sample preparation station positioned within the housing and configured to prepare a sample taken from a specimen in accordance with an assay selected from a database containing a plurality of unique assays;
a sample analysis station positioned within the housing and spaced away from the sample preparation station, the sample analysis station comprising an analyzer comprising a mass spectrometer, the analyzer being dynamically reconfigurable in response to the selected assay to analyze the prepared sample in accordance with the selected assay; and
a transport mechanism including a rotatable table configured to transport a vial containing the prepared sample within the housing and from the sample preparation station to the sample analysis station.

12. The sample preparation and analysis system of claim 11 , wherein the sample preparation station is positioned substantially on one side of the housing, at a height that is greater than a height of a base of an analyzer included in the sample analysis station; and
the analyzer is positioned substantially on the other side of the housing, at a height that is less than a height of a base of the sample preparation station.

13. The sample preparation and analysis system of claim 11 , wherein the sample analysis station further includes one or more liquid chromatography pumps and at least one liquid chromatography mobile phase container, the at least one liquid chromatography mobile phase container being positioned at a height that is greater than a height of the one or more liquid chromatography pumps.

14. The sample preparation and analysis system of claim 11 , wherein the sample preparation station includes at least one of a specimen dock having one or more specimen racks capable of holding a specimen container and a reagent station having one or more reagent racks capable of holding one or more reagent containers.

15. The sample preparation and analysis system of claim 11 further comprising a user interface, wherein the user interface is located centrally along the overall length of the housing between a left-hand sidewall of the housing and a right-hand sidewall of the housing.

16. The sample preparation and analysis system of claim 11 , wherein the sample analysis station further includes an analyzer selected from the group consisting of a liquid chromatograph directly coupled to the mass spectrometer, a gas chromatograph directly coupled to the mass spectrometer, a surface desorption/ionizer directly coupled to the mass spectrometer, a liquid chromatography ultra-violet spectrometer, a fluorescence spectrometer, and combinations thereof.

17. The sample preparation and analysis system of claim 11 , wherein the transport mechanism further includes at least one of a transport assembly, an injector pipette assembly, a fluidic coupler, or combinations thereof.

18. The sample preparation and analysis system of claim 17 , wherein the transport assembly is configured to move the sample in at least one of an x-y direction, an x-y-z direction, or a rotary direction.

19. The sample preparation and analysis system of claim 11 , further comprising a secondary processing station that includes one or more of a mixing station, an incubation station, and a matrix interference removal station and wherein the transport mechanism is configured to transport the prepared sample within the housing and from the sample preparation station to the sample analysis station, from the sample preparation station to the secondary processing station and from the secondary processing station to the sample analysis station.

20. An automated biological specimen preparation and mass spectrometry analysis system for analyzing a plurality of biological specimens, comprising:
a sample preparation station configured to prepare samples taken from the plurality of biological specimens;
a secondary processing station configured to receive samples from the sample preparation station and including

Assignees

• Thermo Fisher Scientific Oy

Inventors

• Dewitte Robert
• Siidorov Juhani
• Nuotio Vesa
• Saukkonen Jukka
• Brann Iii John Edward
• Olney Terry N

Classifications

• G01N2030/628

  Multiplexing, i.e. several columns sharing a single detector · CPC title

• G01N30/02

  Column chromatography · CPC title

• Y10T436/24

  Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry · CPC title

• G01N35/08

  using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis · CPC title

• G01N30/06 Primary

  Preparation · CPC title