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US-12048735-B2 · Jul 30, 2024 · US
Hot-melt extrusion of modified release multi-particulates
US9192578B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9192578-B2 |
| Application number | US-54496309-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 20, 2009 |
| Priority date | Aug 20, 2008 |
| Publication date | Nov 24, 2015 |
| Grant date | Nov 24, 2015 |
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Abstract
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The present invention includes compositions and methods of making a modified release pharmaceutical formulation and a method of preparation for the embedding of modified release multi-particulates into a polymeric or wax-like matrix. The modified release multi-particulates comprise an effective amount of a therapeutic compound having a known or desired drug-release profile. Modified release multi-particulates may include a polymeric coat or may be incorporated into particle or core material. The polymer matrix comprises a thermoplastic polymer or lipophilic carrier or a mixture thereof that softens or melts at elevated temperature and allows the distribution of the modified release multi-particulates in the polymer matrix during thermal processing. Formulation compounds and processing conditions are selected in a manner to preserve the controlled release characteristics and/or drug-protective properties of the original modified release multi-particulates.
First claim
Opening claim text (preview).
What is claimed is: 1. A modified release pharmaceutical composition comprising an extruded thermoplastic polymer matrix in which modified release multi-particulate pellets are uniformly disposed, wherein the modified release multi-particulate pellets have a particle size of from 300 to 800 μm or an average particle size of from 300 to 3000 μm, and further wherein individual multi-particulate pellets comprise a modified release polymer matrix or a modified release polymer coating,…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Operations & Transport · mapped topic
Human Necessities · mapped topic
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Frequently asked questions
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- What does patent US9192578B2 cover?
- The present invention includes compositions and methods of making a modified release pharmaceutical formulation and a method of preparation for the embedding of modified release multi-particulates into a polymeric or wax-like matrix. The modified release multi-particulates comprise an effective amount of a therapeutic compound having a known or desired drug-release profile. Modified release mul…
- Who is the assignee on this patent?
- Mcginity James W, Schilling Sandra U, Univ Texas
- What technology area does this patent fall under?
- Primary CPC classification A61K9/2077. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).