Production of inorganic-organic composite materials by reactive spray-drying

Patent metadata

Field	Value
Publication number	US-9138381-B2
Application number	US-201414175635-A
Country	US
Kind code	B2
Filing date	Feb 7, 2014
Priority date	Feb 8, 2013
Publication date	Sep 22, 2015
Grant date	Sep 22, 2015

Abstract

Process for producing composite materials by reactive spray-drying, where a liquid phase A, which comprises inorganic cations, and a liquid phase B, which comprises anions which, with the inorganic cations, form a salt that is insoluble in the mixture of the liquid phases are sprayed together using at least one multi-substance nozzle, and where at least one hydrophobic active ingredient is present in dissolved form in at least one liquid spraying phase, and where the salt formed from the cations of phase A and the anions of phase B has a solubility of less than 0.02 mol/l in the neutral aqueous medium.

First claim

What is claimed is:

1. A process for producing composite materials by reactive spray-drying, where a liquid phase A, which comprises inorganic cations, and a liquid phase B, which comprises anions which, with the inorganic cations, form a salt that is insoluble in the mixture of the liquid phases are sprayed together using at least one multi-substance nozzle, and where at least one hydrophobic active ingredient is present in dissolved form in at least one liquid spraying phase, and where the salt formed from the cations of phase A and the anions of phase B has a solubility of less than 0.02 mol/l in the neutral aqueous medium.

2. The process according to claim 1 , wherein the inorganic cations of phase A are selected from the group consisting of magnesium ions, calcium ions and zinc ions.

3. The process according to claim 2 , wherein the inorganic cations of phase A used are calcium ions.

4. The process according to claim 1 , wherein the liquid phase A is a solution of salts of the inorganic cations and the salts are selected from the group consisting of calcium chloride, calcium nitrate, calcium acetate, magnesium chloride, magnesium nitrate, magnesium acetate, magnesium citrate, magnesium lactate, zinc chloride, zinc nitrate and zinc acetate.

5. The process according to claim 1 , wherein the liquid phase B used is a solution of salts selected from the group consisting of ammonium, alkali metal or magnesium salts of carbonates, hydrogencarbonates, sulfates, phosphates and hydrogenphosphates.

6. The process according to claim 1 , wherein the liquid phase B used is a solution of salts selected from the group consisting of ammonium, alkali metal or magnesium salts of citric acid, lactic acid and oxalic acid.

7. The process according to claim 1 , wherein the salt formed from the cations of phase A and the anions of phase B that is used is a calcium salt selected from the group consisting of carbonates, phosphates, sulfates, hydroxylapatites, citrates, lactates and oxalates.

8. The process according to claim 1 , wherein the liquid phases are solutions and the solvents present are water or organic solvents or mixtures thereof.

9. The process according to claim 8 , wherein the organic solvent used is ethanol.

10. The process according to claim 1 , wherein the hydrophobic active ingredient is used in the form of an ethanolic or aqueous-ethanolic solution.

11. The process according to claim 1 , wherein a surfactant is added to the liquid phase which comprises the hydrophobic active ingredient.

12. The process according to claim 11 , wherein a surfactant is added in amounts of from 2 to 50% by weight, based on the amount of active ingredient, to the liquid phase which comprises the hydrophobic active ingredient.

13. The process according to claim 1 , wherein a surfactant is added in amounts of from 2 to 50% by weight, based on the amount of active ingredient, to the liquid phase which comprises the hydrophobic active ingredient.

14. The process according to claim 1 , wherein a surfactant selected from the group consisting of polyoxyalkylated fatty acid esters and polyoxyalkylated fatty alcohol ethers is added to the liquid phase which comprises the hydrophobic active ingredient.

15. The process according to claim 1 , wherein the multi-substance nozzle used is an ultrasonic nozzle.

16. The process according to claim 1 , wherein an atomization gas is used during the spray-drying.

17. The process according to claim 1 , where the by spraying drops with a median diameter of 10 to 200 μm μm are produced.

18. The process according to claim 1 , wherein the hydrophobic active ingredient is present in phase A.

19. The process according to claim 1 , wherein the hydrophobic active ingredient is present in phase B.

20. The process according to claim 1 , wherein phase A comprises a calcium salt and phase B comprises ammonium carbonate or sodium carbonate.

21. The process according to claim 1 , wherein phase A comprises a calcium salt and phase B comprises ammonium acetate or sodium acetate.

Assignees

• Basf Se

Inventors

• Kempter Andreas
• Siebert Max
• Debus Heidrun

Classifications

• A61K31/192

  having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid  {(cannabinoids A61K31/658)} · CPC title

• A61K9/145

  with organic compounds · CPC title

• A61K31/58

  containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin (digitoxin {A61K31/7048}) · CPC title

• A61J3/02 Primary

  into the form of powders (pulverising in general B02C) · CPC title

• A61J3/005

  Coating of tablets or the like (coating of sweetmeats or confectionery A23G3/20; coating of granules in general B01J2/006) · CPC title