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US-12059448-B2 · Aug 13, 2024 · US
Neuronal pain pathway
US9107868B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9107868-B2 |
| Application number | US-201213569510-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 8, 2012 |
| Priority date | Mar 21, 2005 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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Abstract
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The present invention relates to the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons, which, in higher animals, is associated with persistent pain. It is based on the discovery that, following injury to an axon of a neuron, an increase in nitric oxide synthase activity results in increased nitric oxide production, which, in turn, activates guanylyl cyclase, thereby increasing levels of cGMP. Increased cGMP results in activation of protein kinase G (“PKG”), which then is retrogradely transported along the axon to the neuron cell body, where it phosphorylates MAPKerk.
First claim
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What is claimed is: 1. A method of treating chronic neuropathic pain in a subject, comprising administering, to a sensory neuron in a dorsal root ganglion of the subject, an effective amount of an agent having formula I: wherein n is 1, 2 or 3; Z is N or CH; wherein X represents one of the following functional groups:…
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- What does patent US9107868B2 cover?
- The present invention relates to the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons, which, in higher animals, is associated with persistent pain. It is based on the discovery that, following injury to an axon of a neuron, an increase in nitric oxide synthase activity results in increased nitric oxide production, which, in turn, activates guany…
- Who is the assignee on this patent?
- Ambron Richard, Sung Ying-Ju, Landry Donald W, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification A61K38/06. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 18 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).