Cellular Adjuvants for Viral Infection
US-2024299521-A1 · Sep 12, 2024 · US
Adhesin-enterotoxin chimera based immunongenic composition against enterotoxigenic Escherichia coli
US9107866B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9107866-B2 |
| Application number | US-98859807-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 11, 2007 |
| Priority date | Jan 10, 2006 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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- Title
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Abstract
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The inventive subject matter relates to an immunogenic composition composed of a chimeric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of the same or different species as the A subunit. The invention also relates to a method of utilizing an adhesin/toxin fusion composition to elicit an immune response.
First claim
Opening claim text (preview).
What is claimed is: 1. An immunogenic composition comprising a purified fusion protein, the fusion protein containing an E. coli minor fimbrial adhesin polypeptide or monomer, wherein the fimbrial adhesin polypeptide or monomer is derived from Class 5 fimbriae or CS3 fimbriae and is operatively connected, directly or via a linker and donor strand polypeptide, to a toxin A subunit polypeptide. 2. The immunogenic composition of claim 1 , wherein the fimbrial ad…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US9107866B2 cover?
- The inventive subject matter relates to an immunogenic composition composed of a chimeric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of th…
- Who is the assignee on this patent?
- Savarino Stephen J, Holmes Randall K, Jobling Michael G, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification A61K39/0258. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 18 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).