Microorganisms genetically engineered to have modified N-glycosylation activity
US-9222083-B2 · Dec 29, 2015 · US
Immunogenic bacterial vesicles with outer membrane proteins
US9206399B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9206399-B2 |
| Application number | US-66678605-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 28, 2005 |
| Priority date | Oct 29, 2004 |
| Publication date | Dec 8, 2015 |
| Grant date | Dec 8, 2015 |
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Abstract
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Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.
First claim
Opening claim text (preview).
The invention claimed is: 1. A Neisseria bacterium, wherein: (i) the bacterium has a knockout mutation of its mItA gene; and (ii) the bacterium has a knockout mutation of its siaA gene. 2. The bacterium of claim 1 , which is N. meningitidis. 3. The bacterium of claim 2 , wherein the N. meningitidis is from serogroup A, B, C, W135 or Y.
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Human Necessities · mapped topic
Human Necessities · mapped topic
- C12N9/1051Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US9206399B2 cover?
- Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provide…
- Who is the assignee on this patent?
- Adu-Bobie Jeannette, Pizza Mariagrazia, Norais Nathalie, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C12N9/1051. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 08 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).