Methods of making drawn silk fibers

Patent metadata

Field	Value
Publication number	US-9074302-B2
Application number	US-201013498722-A
Country	US
Kind code	B2
Filing date	Sep 28, 2010
Priority date	Sep 28, 2009
Publication date	Jul 7, 2015
Grant date	Jul 7, 2015

Abstract

The present invention relates to compositions and method for drawing egel silk fibroin fibers. The resulting fibers can transmit light and hence can be used as optical fiber. Silk fibroin fiber is produced by a method comprising applying an electric field to a solubilized silk fibroin solution to create a silk fibroin gel; converting the silk fibroin gel to a viscous silk liquid; and drawing a silk fiber from the viscous silk liquid. The silk fiber of the invention can be used in materials such as textile, medical sutures, and tissue materials, as well as conferring optical properties into these materials.

First claim

The invention claimed is:

1. A method of producing a silk fiber comprising: providing a silk fibroin gel comprising silk protein in a meta-stable silk I conformation; converting the silk fibroin gel to a viscous silk liquid;
drawing a silk fiber from the viscous silk liquid.

2. The method of claim 1 , wherein converting the silk fibroin gel to the viscous silk liquid comprises quenching the silk fibroin gel in water.

3. The method of claim 2 , wherein the water has a temperature at or below 0° C.

4. The method of claim 2 , wherein the water has a temperature in the range from 40° C. to 80° C.

5. The method of claim 2 , wherein drawing the silk fiber is performed at a temperature ranging from 10° C. to 40° C.

6. The method of claim 2 , wherein converting the silk fibroin gel to the viscous silk liquid further comprises heating the silk fibroin gel prior to the quenching step.

7. The method of claim 6 , wherein the silk fibroin gel is heated to a temperature higher than the temperature of water used in the quenching step.

8. The method of claim 1 , further comprising drying the silk fiber.

9. The method of claim 1 , further comprising contracting the silk fiber.

10. The method of claim 9 , wherein said contracting the silk fiber comprises reducing the ambient humidity to which the silk fiber is exposed.

11. The method of claim 1 , further comprising expanding the silk fiber.

12. The method of claim 11 , wherein said expanding the silk fiber comprises increasing the ambient humidity to which the silk fiber is exposed.

13. The method of claim 12 , wherein the silk fiber is exposed to steam.

14. The method of claim 1 , wherein the silk fibroin gel comprising the silk protein in the meta-stable silk I conformation is produced by applying an electric field to a silk fibroin solution.

15. The method of claim 1 , wherein said converting the silk fibroin gel to the viscous silk liquid comprises heating the silk fibroin gel.

16. The method of claim 15 , wherein the silk fibroin gel is heated to a temperature of about 60° C. to about 75° C.

17. The method of claim 16 , wherein the silk fibroin gel is heated in water.

18. The method of claim 2 , wherein the viscous silk liquid is quenched in water having a temperature selected from the group consisting of: at or below 0° C., in the range of about 10° C. to about 40° C., and in the range of about 40° C. to about 80° C.

19. The method of claim 1 , further comprising subjecting the silk fiber to a post-processing treatment for changing solubility of the silk fiber.

20. The method of claim 19 , further comprising processing the silk fiber with an alcohol treatment or water annealing treatment to generate a water-insoluble silk fiber.

21. The method of claim 1 , further comprising incorporating at least one silk fiber into a composite.

22. The method of claim 21 , wherein the composite comprises combining at least one silk fiber with one or more silk fibers or other fibers, one or more polymers, or other forms of silk material.

23. The method of claim 22 , wherein the composite is a textile-based component or structure, a sensor, an analog to a muscle fiber, a tissue material, a photomechanical actuation, a fiber optic cable, an electro-optic fiber and a smart material.

24. The method of claim 1 , wherein the silk fiber is a silk optical fiber, a silk waveguide, a silk multi-mode fiber, or a silk single mode fiber.

25. The method of claim 1 , wherein the silk fiber further comprises an active agent.

Assignees

• Lo Tim Jia-Ching
• Leisk Gary G
• Kaplan David L
• Tufts College

Inventors

• Lo Tim Jia-Ching
• Leisk Gary G
• Kaplan David L

Classifications

• D01D5/00

  Formation of filaments, threads, or the like · CPC title

• G02B6/02033

  Core or cladding made from organic material, e.g. polymeric material (G02B1/04 takes precedence) · CPC title

• D01F4/02 Primary

  from fibroin · CPC title

• D01D1/02

  Preparation of spinning solutions · CPC title