Method of preventing and/or treating a neurodegenerative disease by administering an extract of Lycoris chejuensis and/or a compound isolated therefrom

Patent metadata

Field	Value
Publication number	US-9044501-B2
Application number	US-60797209-A
Country	US
Kind code	B2
Filing date	Oct 28, 2009
Priority date	Mar 4, 2009
Publication date	Jun 2, 2015
Grant date	Jun 2, 2015

Abstract

Provided are novel use of an extract of Lycoris chejuensis or a compound isolated therefrom for inhibition of β-amyloid production and/or prevention, improvement and/or treatment of a neurodegenerative disease, more specifically a β-amyloid production inhibitor, and/or a composition for prevention or treatment of a neurodegenerative disease containing one or more kinds selected from the group consisting of an extract of Lycoris chejuensis , and/or dihydrolycoricidine, 2-methoxypancracine, lycoricidine, and/or lycoricidinol, as an active ingredient; a method for inhibiting β-amyloid production, and/or preventing and/or treating a neurodegenerative disease using the same; and, a method for preparing the same.

First claim

What is claimed is:

1. A method of treating a neurodegenerative disease comprising administering an extract of Lycoris chejuensis to a patient in need of treatment of a neurodegenerative disease,
wherein the neurodegenerative disease is caused by Aβ 42 production;
wherein the extract comprises lycoricidine as an active ingredient; and
wherein the extract of Lycoris chejuensis is obtained by extracting Lycoris chejuensis with one or more solvents selected from the group consisting of water and C 1 to C 4 lower alcohol.

2. The method according to claim 1 , wherein the neurodegenerative disease is selected from the group consisting of dementia, Parkinson's disease, Alzheimer's disease, Huntington's disease, Pick's Disease, and Parkinson's disease-ALS(amyotrophic lateral sclerosis)-dementia complex.

3. The method according to claim 1 , further comprising extracting the extract obtained according to claim 1 with one or more solvents selected from the group consisting of water, hexane, methylene chloride, ethyl acetate, and C 1 to C 4 lower alcohol.

4. The method according to claim 3 , further comprising extracting the extract obtained according to claim 3 with one or more solvents selected from the group consisting of acetonitrile, C 1 to C 4 lower alcohol, acetone, and water.

5. A method of inhibiting β-amyloid production comprising administering an extract of Lycoris chejuensis to a patient in need of inhibition of β-amyloid production,
wherein the extract comprises lycoricidine as an active ingredient; and
wherein the extract of Lycoris chejuensis is obtained by extracting Lycoris chejuensis with one or more solvents selected from the group consisting of water and C 1 to C 4 lower alcohol.

6. The method according to claim 5 , further comprising extracting the extract obtained according to claim 5 with one or more solvents selected from the group consisting of water, hexane, methylene chloride, ethyl acetate, and C 1 to C 4 lower alcohol.

7. The method according to claim 6 , further comprising extracting the extract obtained according to claim 6 with one or more solvents selected from the group consisting of acetonitrile, C 1 to C 4 lower alcohol, acetone, and water.

Assignees

• Yang Hyun-Ok
• Kwon Hak-Cheol
• Park Jin-Soo
• Chung Sung-Kwon
• Kim Myung-Soo
• Korea Inst Sci & Tech

Inventors

• Yang Hyun-Ok
• Kwon Hak-Cheol
• Park Jin-Soo
• Chung Sung-Kwon
• Kim Myung-Soo

Classifications

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/14

  for treating abnormal movements, e.g. chorea, dyskinesia · CPC title

• A61P25/16

  Anti-Parkinson drugs · CPC title

• A61K36/896 Primary

  Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus · CPC title

• A61K31/4741 Primary

  condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline · CPC title