Aloe vera extract for personal care compositions

Patent metadata

Field	Value
Publication number	US-10449143-B2
Application number	US-201515304077-A
Country	US
Kind code	B2
Filing date	Apr 2, 2015
Priority date	Apr 17, 2014
Publication date	Oct 22, 2019
Grant date	Oct 22, 2019

Abstract

The invention relates to a specific fraction of Aloe vera extract for enhancing tight junction in skin cells. The invention more particularly relates to use of such a fraction in skin, oral and hair care compositions. The inventive extract of Aloe vera comprises 60 to 95% by weight of polysaccharides having a molecular weight in the range of 2 to 3 kDa, and less than 5% polyphenols, wherein the polysaccharides are hydrolysed by trifiuoroacetic acid.

First claim

The invention claimed is:

1. A personal care composition comprising:
a) 0.1 to 10% by wt. of an extract of Aloe vera comprising:
(i) 60 to 95% by weight of hydrolysed polysaccharides having a molecular weight in the range of 2 to 3 kDa; and
(ii) less than 5% by weight polyphenols;
wherein the polysaccharides are hydrolysed by trifluoroacetic acid (TFA); and

b) 10 to 99.9% by wt. of a cosmetically acceptable base which is selected from the group consisting of fatty acids, soaps of fatty acids, water and mixtures thereof;

wherein higher than 30% by weight of said polysaccharides in the extract comprise the polymer backbone

2. The composition of claim 1 , wherein the extract comprises less than 2% by weight polyphenols.

3. The composition of claim 1 , wherein the cosmetically acceptable base is selected from the group consisting of a fatty acid, an alkali metal salt of a fatty acid and water.

4. The composition of claim 3 , wherein the fatty acid, an alkali metal salt of the fatty acid and water.

5. The composition of claim 4 , wherein the fatty acid is present in an amount of from about 1% to about 25% by weight of the composition.

6. The composition of claim 4 , wherein the fatty acid comprises C 14 to C 18 fatty acid.

7. The composition of claim 4 , wherein the alkali metal salt of fatty acid comprises a sodium salt or a potassium salt of a fatty acid.

8. The composition of claim 4 , wherein the alkali metal salt of a fatty acid is present in an amount of from about 0.1% to about 10% by weight of the composition.

9. The composition of claim 3 , wherein water is present in an amount of from about 35% to about 90% by weight of the composition.

10. The composition of claim 1 , comprising from about 1 to about 5% by wt. of an extract of Aloe vera.

11. An extract of Aloe vera comprising:
(i) 60 to 95% by weight of hydrolysed polysaccharides having a molecular weight in the range of 2 to 3 kDa; and
(ii) less than 5% by weight polyphenols;
wherein the polysaccharides are hydrolysed by trifluoracetic acid (TFA), and
wherein higher than 30% by weight of said polysaccharides in the extract comprise the polymer backbone

12. A method of providing enhanced immunity to an external surface of a human or animal body in need thereof, comprising the step of topically applying an effective amount of a composition as claimed in claim 1 , wherein the external surface enhanced immunity provides a measurable change in trans-epithelial electrical resistance (TEER).

13. The composition of claim 1 , having a trans-epithelial electrical resistance (TEER) value greater than the TEER value of compositions comprising Aloe vera extract not comprising 60 to 95% by weight of hydrolysed polysaccharides having a molecular weight in the range of 2 to 3 kDa.

Assignees

• Conopco Inc

Inventors

• Kalathil Ramitha
• Majumdar Amitabha
• Majumder Suman
• Taduri Jagannath

Classifications

• A61P37/04

  Immunostimulants · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61K8/9794 Primary

  Liliopsida [monocotyledons] · CPC title

• A61K36/886

  Aloeaceae (Aloe family), e.g. aloe vera · CPC title

• A61K31/715

  Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters · CPC title