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Ketoreductase-mediated stereoselective route to alpha chloroalcohols
US9029112B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9029112-B2 |
| Application number | US-201414313465-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 24, 2014 |
| Priority date | Jun 22, 2009 |
| Publication date | May 12, 2015 |
| Grant date | May 12, 2015 |
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Abstract
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The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
First claim
Opening claim text (preview).
What is claimed is: 1. A recombinant polynucleotide encoding an engineered ketoreductase polypeptide capable of converting (S)-tert-butyl 4-chloro-3-oxo-l-phenylbutan-2-ylcarbamate to tert-butyl (2S,3R)-4-chloro-3-hydroxy-l-phenylbutan-2-ylcarbamate with a relative activity at least 1.2-fold that of the polypeptide of SEQ ID NO:2, wherein the engineered ketoreductase polypeptide comprises an amino acid sequence at least 90% identical to SEQ ID NO:2 and includes one or more amino ac…
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- C12N9/0006Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C12N9/0008Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US9029112B2 cover?
- The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
- Who is the assignee on this patent?
- Codexis Inc
- What technology area does this patent fall under?
- Primary CPC classification C12N9/0006. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 12 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).