Thrombin inhibitor
US-9217027-B2 · Dec 22, 2015 · US
Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US9028800B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9028800-B2 |
| Application number | US-201414273163-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 8, 2014 |
| Priority date | Jan 11, 2007 |
| Publication date | May 12, 2015 |
| Grant date | May 12, 2015 |
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Abstract
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The present application discloses compositions and methods of synthesis and use of 18 F or 19 F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18 F or 19 F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 18 F or 19 F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the labeled molecule may be used for imaging in a subject without purification after labeling.
First claim
Opening claim text (preview).
What is claimed is: 1. A composition comprising an 19 F- or 18 F-labeled targeting molecule comprising a bifunctional chelating agent of the structure wherein R 1 and R 2 are independently selected from the group consisting of —CH 2 —COOH —CH 2 —CH 2 —OH —CH(CH 3 )—COOH —CH(C 6 H 5 )—COOH…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US9028800B2 cover?
- The present application discloses compositions and methods of synthesis and use of 18 F or 19 F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18 F or 19 F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may be directly or indirectly attached to the targetin…
- Who is the assignee on this patent?
- Immunomedics Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K51/08. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 12 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).