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Ficolin-3 assay
US9012154B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9012154-B2 |
| Application number | US-201013377121-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 9, 2010 |
| Priority date | Jun 10, 2009 |
| Publication date | Apr 21, 2015 |
| Grant date | Apr 21, 2015 |
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Abstract
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The present invention relates to methods for detecting Ficolin-3 dependent activation of the lectin pathway of complement, methods for identifying abnormalities in Ficolin-3, and methods for screening for deficiencies/and or identifying abnormalities in any downstream components of the Ficolin-3 dependent activation of the lectin pathway of 5 complement using an acetylated Ficolin-3 ligand, said methods generally comprising the steps of: (a) providing a sample of blood, serum, plasma, another body fluid or an extract thereof; (b) (optionally) preventing in the sample activation of the classical pathway and/or the alternative pathway and/or any non-Ficolin-3 mediated activation of the lectin pathway; (c) acetylating a molecule; (d) contacting said acetylated molecule 10 with said sample, in conditions that permit specific binding of Ficolin-3 to said acetylated molecule, and, (e) detecting and quantifying specific binding of the Ficolin-3 to said acetylated molecule, (f) determining in the sample complement activation and/or deposition by the detection of a C2, C3, C4 and/or a C5 cleavage product and/or by detecting any of the terminal complement complex components C6, C7, C8 or C9 or 15 the C5b-9 terminal complement complex as such. The present invention also provides assays and kits comprising the methods of the invention.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for detecting Ficolin-3 binding to a Ficolin-3 ligand, the method comprising: detecting a complex of Ficolin-3 and a Ficolin-3 ligand, wherein the Ficolin-3 ligand is an acetylated protein that is immobilized on a support. 2. The method according to claim 1 , wherein detecting a complex of Ficolin-3 and a Ficolin-3 ligand comprises: contacting the Ficolin-3 ligand with a sample of blood, serum, plasma, another body flui…
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- G01N33/564Primary
Physics · mapped topic
Physics · mapped topic
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- What does patent US9012154B2 cover?
- The present invention relates to methods for detecting Ficolin-3 dependent activation of the lectin pathway of complement, methods for identifying abnormalities in Ficolin-3, and methods for screening for deficiencies/and or identifying abnormalities in any downstream components of the Ficolin-3 dependent activation of the lectin pathway of 5 complement using an acetylated Ficolin-3 ligand, sai…
- Who is the assignee on this patent?
- Garred Peter, Honore Christian, Rigshospitalet, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/564. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).