Surface-independent, surface-modifying, multifunctional coatings and applications thereof

Patent metadata

Field	Value
Publication number	US-8999452-B2
Application number	US-201313939386-A
Country	US
Kind code	B2
Filing date	Jul 11, 2013
Priority date	Oct 19, 2006
Publication date	Apr 7, 2015
Grant date	Apr 7, 2015

Abstract

The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (SMA) such as dopamine so as to modify the substrate surface to include at least one reactive moiety. In another version of the invention, a secondary reactive moiety is applied to the SMA-treated substrate to yield a surface-modified substrate having a specific functionality.

First claim

We claim:

1. A method of modifying a substrate surface to provide a desired functionality, the method comprising:
a) contacting at least a portion of the substrate surface with an alkaline, aqueous solution under oxidative conditions, the solution comprising a surface-modifying agent according to Formula I:

wherein each of R 1 , R 2 , R 3 , R 4 and R 5 is independently selected from the group consisting of a thiol, a primary amine, a secondary amine, a nitrile, an aldehyde, an imidazole, an azide, a halide, a hydrogen, a hydroxyl, a carboxylic acid, and an aldehyde, provided at least one of R 1 , R 2 , R 3 , R 4 and R 5 is not a hydrogen atom;
wherein x ranges from 0 to 10 and wherein y ranges from 0 to 10, provided that x or y is at least 1; and
wherein the substrate surface is modified; and
b) contacting the surface-modified substrate with a reactive moiety comprising a metal, wherein the reactive moiety reacts with and is bound to the modified surface.

2. The method of claim 1 wherein the reactive moiety comprises a nucleophile.

Assignees

• Messersmith Phillip B
• Lee Haeshin
• Univ Northwestern

Inventors

• Messersmith Phillip B
• Lee Haeshin

Classifications

• C23C18/1608

  from pretreatment step, i.e. selective pre-treatment · CPC title

• A61L2420/08

  Coatings comprising two or more layers · CPC title

• C08J7/123 Primary

  Treatment by wave energy or particle radiation (C08J7/18 takes precedence) · CPC title

• C23C18/1834

  Use of organic or inorganic compounds other than metals, e.g. activation, sensitisation with polymers · CPC title

• B05D1/185

  applying monomolecular layers (B05D1/204 takes precedence) · CPC title