Polyconjugates for delivery of RNAi triggers to tumor cells in vivo
US-9487556-B2 · Nov 8, 2016 · US
Dimeric IAP inhibitors
US8993523B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993523-B2 |
| Application number | US-201113993198-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 13, 2011 |
| Priority date | Dec 13, 2010 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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The present invention provides compounds of formula M-L-M′ (where M and M′ are each independently a monomeric moiety of Formula (I) and L is a linker). The dimeric compounds have been found to be effective in promoting apoptosis in rapidly dividing cells. (I)
First claim
Opening claim text (preview).
What is claimed is: 1. A compound of Formula M-L-M′, wherein M and M′ are each independently a monomeric moiety of Formula (I) wherein, R 1 is (C 1 -C 4 )alkyl, deuterated methyl, or hydrogen; R 2 is (C 1 -C 4 )alkyl or hydrogen; R 3 is (C 1 -C 4 )alkyl or hydrogen, or R 1 or R 2 along with the nitrogen to which R 1 or R 2 is attached is taken together with R 3 t…
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- C07K5/06043Primary
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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Frequently asked questions
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- What does patent US8993523B2 cover?
- The present invention provides compounds of formula M-L-M′ (where M and M′ are each independently a monomeric moiety of Formula (I) and L is a linker). The dimeric compounds have been found to be effective in promoting apoptosis in rapidly dividing cells. (I)
- Who is the assignee on this patent?
- Chen Zhuoliang, Straub Christopher Sean, Novartis Ag
- What technology area does this patent fall under?
- Primary CPC classification C07K5/06043. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).