Chamber for transplantation and device for transplantation
US-11856946-B2 · Jan 2, 2024 · US
Bio-matrix stretcher
US8993312B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993312-B2 |
| Application number | US-67588208-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 28, 2008 |
| Priority date | Aug 30, 2007 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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Embodiments provide techniques for measuring and characterizing the dynamics of cell traction forces. Tunable elastic gel substrates can be disposed in multi-well plates. The gels can be of a uniform predetermined thickness. A multi-well plate can be loaded with gels of different shear moduli. An array of punch indenters can be attached to a loading platen such that the each indenter is aligned to a gel substrate. The indenters can apply tensile or compressive strains to the gel substrates. The magnitude, duration, and frequency of the strain can be controlled by a motor assembly coupled to a control system. The apparatus can be disposed in an incubator for long term cell culture experiments. The cell culture can be observed while a strain is applied. A ring-shaped indenter can be mounted on a microscope, coaxial to the objective lens, and lowered by a calibrated amount onto the underlying gel.
First claim
Opening claim text (preview).
What is claimed is: 1. An apparatus comprising: a closed-bottom well; a tunable elastic substrate disposed within the closed-bottom well, the tunable elastic substrate having a cell plating side and a second side affixed to a bottom of the closed-bottom well, the tunable elastic substrate comprising a gel; a cell plating area disposed on a cell plating side of the tunable elastic substrate; and a ring-shaped punch indenter with an inner diameter that is larger than the size…
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Chemistry & Metallurgy · mapped topic
- C12N5/0068Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US8993312B2 cover?
- Embodiments provide techniques for measuring and characterizing the dynamics of cell traction forces. Tunable elastic gel substrates can be disposed in multi-well plates. The gels can be of a uniform predetermined thickness. A multi-well plate can be loaded with gels of different shear moduli. An array of punch indenters can be attached to a loading platen such that the each indenter is aligned…
- Who is the assignee on this patent?
- Krishnan Ramaswamy, Park Chan Young, Fredberg Jeffrey, and 4 more
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0068. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).