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Tissue-engineered silk organs
US9102916B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9102916-B2 |
| Application number | US-52863408-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 27, 2008 |
| Priority date | Feb 27, 2007 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Abstract
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This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.
First claim
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We claim: 1. A lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells, wherein the tissue layer comprises micropores, and wherein spacing between the micropores is 50 μm to 100 μm, and average diameter of the micropores ranges from 800 nm to 10 μm. 2. The tissue layer of claim 1 , wherein the tissue-specific cells deposit extracellular matrix on said substrate. 3. The tissue layer of claim 1 , wh…
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Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Physics · mapped topic
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- What does patent US9102916B2 cover?
- This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engine…
- Who is the assignee on this patent?
- Kaplan David L, Omenetto Fiorenzo, Marchant Jeffrey K, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification A61L27/227. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 11 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).