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Methods and kits for diagnosing Sjögren's syndrome
US8969015B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8969015-B2 |
| Application number | US-201314078020-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 12, 2013 |
| Priority date | Nov 9, 2012 |
| Publication date | Mar 3, 2015 |
| Grant date | Mar 3, 2015 |
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Abstract
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The invention features methods and kits for determining the presence of, or a predisposition to develop, Sjögren's syndrome in humans. The invention features methods to detect changes in the levels of one or more LMP-2 protein isoforms, in particular phosphorylated isoforms of LMP-2, and to detect changes in cellular protein phosphorylation and ubiquitination in samples from Sjögren's patients.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for determining the presence of, or a predisposition to develop, Sjögren's syndrome in a human comprising: a) measuring the level of an LMP-2 protein isoform in a first sample obtained from said human comprising separating said LMP-2 protein isoform using isoelectric focusing based on pl, wherein said LMP-2 protein isoform has a pl in the range of 4.5-5.5, and detecting said LMP-2 protein with an anti-LMP-2 antibody; and b) measuring a ch…
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Physics · mapped topic
- G01N33/564Primary
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
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- What does patent US8969015B2 cover?
- The invention features methods and kits for determining the presence of, or a predisposition to develop, Sjögren's syndrome in humans. The invention features methods to detect changes in the levels of one or more LMP-2 protein isoforms, in particular phosphorylated isoforms of LMP-2, and to detect changes in cellular protein phosphorylation and ubiquitination in samples from Sjögren's patients.
- Who is the assignee on this patent?
- Gen Hospital Corp
- What technology area does this patent fall under?
- Primary CPC classification G01N33/564. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Mar 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).