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US-2015374780-A1 · Dec 31, 2015 · US
Neisseria porin proteins
US8962801B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962801-B2 |
| Application number | US-201113812872-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 1, 2011 |
| Priority date | Jul 30, 2010 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
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Neisseria meningitidis PorA constructs are provided which have one or more disrupted variable regions created by insertion of entire conserved regions or conserved region amino acids. The highly immunogenic variable regions of PorA are responsible for eliciting strain-specific immune responses that are not broadly protective, so disruption of the variable regions directs the immune response against conserved region epitopes to effectively immunize against a broader spectrum of N. meningitidis strains. Also provided are encoding nucleic acids, genetic constructs, host cells expressing the PorA constructs and compositions, kits and methods for detection and treatment of Neisseria meningitidis infections.
First claim
Opening claim text (preview).
The invention claimed is: 1. An isolated protein comprising the amino acid sequence of a PorA protein of Neisseria meningitides , wherein: one or more variable regions of the PorA protein are disrupted by replacing the one or more variable regions or a plurality of contiguous amino acids of the one or more variable regions with one or more entire PorA conserved regions, or at least six (6) contiguous conserved region amino acids of the one or more entire PorA conserved regions;…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
- C07K14/22Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8962801B2 cover?
- Neisseria meningitidis PorA constructs are provided which have one or more disrupted variable regions created by insertion of entire conserved regions or conserved region amino acids. The highly immunogenic variable regions of PorA are responsible for eliciting strain-specific immune responses that are not broadly protective, so disruption of the variable regions directs the immune response ag…
- Who is the assignee on this patent?
- Jennings Michael Paul, Peak Ian Richard Anselm, Univ Griffith
- What technology area does this patent fall under?
- Primary CPC classification C07K14/22. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).