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Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
US8962346B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962346-B2 |
| Application number | US-201213423050-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 16, 2012 |
| Priority date | Jul 8, 2010 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
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Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyte in a detection region of the sedimentation channel. In some examples, the sedimentation particles and labeling agent may have like charges to reduce non-specific binding of labeling agent and sedimentation particles. In some examples, the density medium is provided with a separation layer for stabilizing the assay during storage and operation. In some examples, the sedimentation channel may be provided with a generally flat sedimentation chamber for dispersing the particle pellet over a larger surface area.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for conducting an assay comprising: layering a mixture on a density medium in an assay area, wherein the mixture includes a sample, a first separation layer fluid, and sedimentation particles, wherein the sedimentation particles have a density greater than the density medium, and wherein said layering a mixture comprises forming, with the first separation layer fluid, an interface between the density medium and the sample, between the sample and the…
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Physics · mapped topic
Physics · mapped topic
- G01N33/54313Primary
Physics · mapped topic
Operations & Transport · mapped topic
Operations & Transport · mapped topic
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Frequently asked questions
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- What does patent US8962346B2 cover?
- Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyt…
- Who is the assignee on this patent?
- Schaff Ulrich Y, Koh Chung-Yan, Sommer Gregory J, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/54313. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).