Sensing chip, sensing chip manufacturing method, sensing kit, measuring method and measuring device
US-2024319093-A1 · Sep 26, 2024 · US
Label-free detection of nanoparticles and biological molecules using microtoroid optical resonators
US2015301034A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2015301034-A1 |
| Application number | US-201514658063-A |
| Country | US |
| Kind code | A1 |
| Filing date | Mar 13, 2015 |
| Priority date | Mar 14, 2014 |
| Publication date | Oct 22, 2015 |
| Grant date | — |
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Abstract
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Systems and methods are provided for detecting one or more particles such as individual unlabeled molecules or single nanoparticles. In examples described herein, optical energy is introduced into a microtoroid or other microcavity to generate an evanescent field. The microcavity has a functionalized outer surface that has been functionalized with a chemically or biologically active substance such as an antibody, antigen or protein. An indication of a particle bound to the functionalized outer surface of the microcavity is then detected based on a reactive interaction between the particle and the evanescent field while using frequency locking, balanced detection and various filtering techniques. The frequency locking, balanced detection and filtering techniques reduce the signal-to-noise ratio (SNR) of the detection system so that single nanoparticles (e.g. 2.5 nanometers (nm) in radius) and individual molecules (e.g. 15.5 kilo-Dalton (kDa) in size) can be detected in aqueous solution in some examples.
First claim
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What is claimed is: 1 . A method for particle detection, comprising: introducing electromagnetic energy into a microcavity to generate an evanescent field extending beyond an outer surface of the microcavity; and detecting an indication of a particle bound to the outer surface of the microcavity based on a reactive interaction between the particle and the evanescent field using frequency locking and balanced detection. 2 . The method of claim 1 wherei…
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Physics · mapped topic
- G01N33/54373Primary
Physics · mapped topic
- G01N21/7746Primary
Physics · mapped topic
Physics · mapped topic
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- What does patent US2015301034A1 cover?
- Systems and methods are provided for detecting one or more particles such as individual unlabeled molecules or single nanoparticles. In examples described herein, optical energy is introduced into a microtoroid or other microcavity to generate an evanescent field. The microcavity has a functionalized outer surface that has been functionalized with a chemically or biologically active substance s…
- Who is the assignee on this patent?
- California Inst Of Techn
- What technology area does this patent fall under?
- Primary CPC classification G01N33/54373. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Thu Oct 22 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).