Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof
US-11044931-B2 · Jun 29, 2021 · US
US8952003B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8952003-B2 |
| Application number | US-201013386542-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 22, 2010 |
| Priority date | Jul 24, 2009 |
| Publication date | Feb 10, 2015 |
| Grant date | Feb 10, 2015 |
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The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; X a and X b are the same or different, and represent a bond or the like; R 1 , R 2 , R 3 , R 4 , R 7 and R 8 are the same or different, and represent a hydrogen atom or the like; R 5 and R 6 are the same or different, and represent a hydrogen atom or the like; R 9 represents a hydrogen atom or the like; R 10 and R 11 together represent a bond or the like; and R 12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.
Opening claim text (preview).
The invention claimed is: 1. A sterol derivative represented by the general formula (I): [wherein Y represents optionally substituted lower alkyl or optionally substituted lower alkenyl, X a and X b are the same or different, and represent a bond or —NR a — (wherein R a represents a hydrogen atom, optionally substituted lower alkyl, optionally substituted cycloalky…
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