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Ketol-acid reductoisomerase using NADH
US8945899B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8945899-B2 |
| Application number | US-63790509-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 15, 2009 |
| Priority date | Dec 20, 2007 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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Methods for the evolution of NADPH specific ketol-acid reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.
First claim
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What is claimed is: 1. A recombinant mutant ketol-acid reductoisomerase enzyme having the amino acid sequence selected from the group consisting of SEQ ID NO: 24, 25, 26, 27, 28, 67, 68, 70, 75, 79, 80, 81 and 82 having ketol-acid reductoisomerase activity. 2. A method for evolution of an NADPH specific ketol-acid reductoisomerase enzyme to an NADH using form comprising: a) providing a mutant enzyme having an amino acid sequence selected from the group consisti…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Cross-Sectional Technologies · mapped topic
Chemistry & Metallurgy · mapped topic
- C12N9/0006Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US8945899B2 cover?
- Methods for the evolution of NADPH specific ketol-acid reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.
- Who is the assignee on this patent?
- Li Yougen, Liao Der-Ing, Nelson Mark J, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C12N9/0006. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).