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Method for screening for compound capable of enhancing or inhibiting OATP1B1 transport activity, and method for determining expression level of OATP1B1
US8945865B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8945865-B2 |
| Application number | US-201214003541-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 6, 2012 |
| Priority date | Mar 10, 2011 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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The present invention provides a method of screening for a compound that enhances or inhibits the transport activity of OATP1B1, using dichlorofluorescein. The present invention also provides a use of dichlorofluorescein in measurement of the expression level of OATP1B1. The present invention further provides a method for measuring the expression level of OATP1B1 in test cells, using dichlorofluorescein. The present invention further provides a use of a kit including dichlorofluorescein and positive cells expressing OATP1B1 in measurement of the expression level of OATP1B1 in test cells.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of screening for a compound that enhances or inhibits a transport activity of OATP1B1, comprising: a step of preparing a cell expressing OATP1B1; a step of bringing dichlorofluorescein and a test compound into contact with the cell; a step of measuring a fluorescence intensity of dichlorofluorescein taken up by the cell; and a step of determining the test compound as a compound that enhances the transport activity of OATP1B1 in a case th…
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Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
- G01N33/5008Primary
Physics · mapped topic
Physics · mapped topic
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- What does patent US8945865B2 cover?
- The present invention provides a method of screening for a compound that enhances or inhibits the transport activity of OATP1B1, using dichlorofluorescein. The present invention also provides a use of dichlorofluorescein in measurement of the expression level of OATP1B1. The present invention further provides a method for measuring the expression level of OATP1B1 in test cells, using dichlorofl…
- Who is the assignee on this patent?
- Izumi Saki, Komori Takafumi, NOZAKI Yoshitane, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/5008. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).