Ophthalmic devices derived from grafted polymeric networks and processes for their preparation and use
US-2024018294-A1 · Jan 18, 2024 · US
US8944592B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8944592-B2 |
| Application number | US-201313948206-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 23, 2013 |
| Priority date | Jul 30, 2010 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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What is claimed is: 1. A readily-usable silicone hydrogel contact lens, comprising a silicone hydrogel material and a crosslinked hydrophilic coating thereon, wherein the crosslinked hydrophilic coating is attached onto the silicone hydrogel contact lens through neutral, hydroxyl-containing covalent linkages each of which is obtained by reacting, in a crosslinking reaction at a temperature from about 40° C. to about 140° C., one positively-charged azetidinium group with one functio…
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