Silicone hydrogel lens with a crosslinked hydrophilic coating

Patent metadata

Field	Value
Publication number	US-9507173-B2
Application number	US-201514962354-A
Country	US
Kind code	B2
Filing date	Dec 8, 2015
Priority date	Jul 30, 2010
Publication date	Nov 29, 2016
Grant date	Nov 29, 2016

Abstract

The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

First claim

What is claimed is:

1. A readily-usable silicone hydrogel contact lens, comprising:
a preformed silicone hydrogel contact lens;
a reactive base coating on the preformed silicone hydrogel contact lens, wherein the reactive base coating comprises at least one layer of a reactive polymer having pendant carboxyl groups; and
a crosslinked hydrophilic coating which is covalently attached onto the reactive base coating through neutral, hydroxyl-containing covalent linkages each of wh…

Assignees

• Novartis Ag

Inventors

• Qiu Yongxing
• Samuel Newton T
• Pruitt John Dallas
• Kolluru Chandana
• Medina Arturo Norberto
• Winterton Lynn Cook
• Wu Daqing
• Qian Xinming
• Nelson Jared

Classifications

• B29D11/00067 Primary

  Operations & Transport · mapped topic

• G02C7/04

  Physics · mapped topic

• C09D5/1681

  Chemistry & Metallurgy · mapped topic

• G02B1/18

  Physics · mapped topic

• G02B1/043 Primary

  Physics · mapped topic