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Peptide-based peroxidase inhibitors and methods of using same
US8937039B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8937039-B2 |
| Application number | US-201314081695-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 15, 2013 |
| Priority date | Oct 5, 2009 |
| Publication date | Jan 20, 2015 |
| Grant date | Jan 20, 2015 |
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Abstract
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The present invention provides peptide-based peroxidase inhibitors having the formula AA 1 -AA 2 -AA 3 , wherein AA 1 is a positively charged, negatively charged or neutral amino acid, AA 2 is a redox active amino acid, and AA 3 is an amino acid possessing a reducing potential such that AA 3 is capable of undergoing a redox reaction with a radical of amino acid AA 2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
First claim
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We claim: 1. A method of inhibiting peroxidase activity in a subject, the method comprising administering to the subject a peptide-based peroxidase inhibitor having the formula AA 1 -AA 2 -AA 3 , wherein AA 1 is a positively charged, negatively charged or neutral amino acid, AA 2 is a redox active amino acid, and AA 3 is an amino acid possessing a reducing potential such that AA 3 is capable of undergoing a redox reaction with a radical of amino acid AA 2 ; or a retro or retro-…
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Human Necessities · mapped topic
- C07K5/0815Primary
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US8937039B2 cover?
- The present invention provides peptide-based peroxidase inhibitors having the formula AA 1 -AA 2 -AA 3 , wherein AA 1 is a positively charged, negatively charged or neutral amino acid, AA 2 is a redox active amino acid, and AA 3 is an amino acid possessing a reducing potential such that AA 3 is capable of undergoing a redox reaction with a radical of amino acid AA 2 or a retro or retro-inv…
- Who is the assignee on this patent?
- Zhang Hao, Shi Yang, Xu Hao, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07K5/0815. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 20 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).