Rosuvastatin calcium and process for producing intermediate thereof
US-2024360086-A1 · Oct 31, 2024 · US
O-phosphoserine-producing microorganism and method for producing o-phosphoserine or l-cysteine using the same
US2025075221A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2025075221-A1 |
| Application number | US-202218725731-A |
| Country | US |
| Kind code | A1 |
| Filing date | Dec 27, 2022 |
| Priority date | Dec 31, 2021 |
| Publication date | Mar 6, 2025 |
| Grant date | — |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The present application relates to a microorganism in which an activity of erythronate-4-phosphate dehydrogenase is weakened; a method for producing O-phosphoserine, cysteine, or cysteine derivatives using the microorganism; a composition for producing O-phosphoserine comprising the microorganism; and the use of the microorganism in the production of O-phosphoserine, cysteine, and cysteine derivatives.
First claim
Opening claim text (preview).
1 . An O-phosphoserine-producing microorganism, in which an activity of erythronate-4-phosphate dehydrogenase is weakened. 2 . The microorganism of claim 1 , wherein an initiation codon of a polynucleotide encoding the erythronate-4-phosphate dehydrogenase is substituted with TTG or CTG. 3 . The microorganism of claim 2 , wherein the microorganism has an increased O-phosphoserine productivity compared to a microorganism in which the initiation codon of a polynucleotide encoding the erythronate-4-phosphate dehydrogenase is GTG or ATG. 4 . The microorganism of claim 1 , wherein an YhhS protein activity is further enhanced. 5 . The microorganism of claim 1 , wherein an activity of phosphoserine phosphatase is further weakened. 6 . The microorganism of claim 1 , wherein a protein activity of YhhS, phosphoserine aminotransferase, or a combination thereof is introduced or enhanced. 7 . The microorganism of claim 1 , wherein the microorganism is a microorganism of the genus Escherichia. 8 . The microorganism of claim 7 , wherein the microorganism of the genus Escherichia is E. coli. 9 . A method for producing O-phosphoserine, comprising culturing an O-phosphoserine-producing microorganism, in which an activity of erythronate-4-phosphate dehydrogenase is weakened, in a medium. 10 . A method for producing cysteine or a derivative thereof, comprising: a) culturing an O-phosphoserine-producing microorganism, in which an activity of erythronate-4-phosphate dehydrogenase is weakened, in a medium to produce O-phosphoserine or a medium containing the same; and b) reacting O-phosphoserine sulfhydrylase (OPSS) or a microorganism expressing the same; O-phosphoserine produced in step a) or a medium containing the same; and a sulfide.
Assignees
Inventors
Classifications
Phosphoserine phosphatase (3.1.3.3) · CPC title
Phosphoserine transaminase (2.6.1.52) · CPC title
O-Phosphoserine sulfhydrylase (2.5.1.65) · CPC title
4-Phosphoerythronate dehydrogenase (1.1.1.290) · CPC title
Methionine; Cysteine; Cystine · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US2025075221A1 cover?
- The present application relates to a microorganism in which an activity of erythronate-4-phosphate dehydrogenase is weakened; a method for producing O-phosphoserine, cysteine, or cysteine derivatives using the microorganism; a composition for producing O-phosphoserine comprising the microorganism; and the use of the microorganism in the production of O-phosphoserine, cysteine, and cysteine deri…
- Who is the assignee on this patent?
- Cj Cheiljedang Corp
- What technology area does this patent fall under?
- Primary CPC classification C12N9/0006. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu Mar 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).