Acyclic nucleoside phosphonate diesters
US-10449207-B2 · Oct 22, 2019 · US
US2024217999A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2024217999-A1 |
| Application number | US-202318541692-A |
| Country | US |
| Kind code | A1 |
| Filing date | Dec 15, 2023 |
| Priority date | Dec 27, 2022 |
| Publication date | Jul 4, 2024 |
| Grant date | — |
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Process for preparing monophosphites and the compound used for the preparation.
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1 . Process comprising the process steps of: a) initially charging a compound Y, wherein Y is a five-membered ring in which at least one carbon atom has been replaced by a nitrogen atom; b) adding P(NX 2 ) 3 , where X is —(C 1 -C 6 )-alkyl; c) adding a compound according to the formula (I): wherein R 1 , R 2 , R 3 are selected from: —H, —(C 1 -C 12 )-alkyl, —O—(C 1 -C 12 )-alkyl, —(C 6 -C 10 )-aryl, —CN, —NO 2 . 2 . Process according to claim 1 , wherein the five-membered ring (Y) has at least one double bond. 3 . Process according to claim 1 , wherein the five-membered ring (Y) has two double bonds. 4 . Process according to claim 1 , wherein the five-membered ring (Y) has at least one N—H bond. 5 . Process according to claim 1 , wherein the five-membered ring (Y) has at least two nitrogen atoms. 6 . Process according to claim 1 , wherein the five-membered ring (Y) has at least three nitrogen atoms. 7 . Process according to claim 1 , wherein the five-membered ring (Y) has four nitrogen atoms. 8 . Process according to claim 1 , wherein Y is the following compound: 9 . Process according to claim 1 , wherein X is —(C 1 -C 2 )-alkyl. 10 . Process according to claim 1 , wherein X is —CH 3 . 11 . Process according to claim 1 , wherein R 1 , R 2 , R 3 are selected from: —H, —(C 1 -C 12 )-alkyl, —O—(C 1 -C 12 )-alkyl, —(C 6 -C 10 )-aryl. 12 . Process according to claim 1 , wherein R 1 , R 2 , R 3 are selected from: —H, —(C 1 -C 12 )-alkyl, —O—(C 1 -C 12 )-alkyl. 13 . Process according to claim 1 , comprising the additional process step d) of: d) adding a solvent. 14 . Process according to claim 13 , wherein the solvent is selected from: acetonitrile (ACN), toluene, xylene, THF, heptane. 15 . Compound according to the formula (3):
having four or more nitrogen atoms as the only ring hetero atoms · CPC title
with hydroxyaryl compounds · CPC title
Five-membered rings · CPC title
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