Novel peptide having anti-inflammatory and tissue regenerative actions

Patent metadata

Field	Value
Publication number	US-2024209022-A1
Application number	US-202318312110-A
Country	US
Kind code	A1
Filing date	May 4, 2023
Priority date	Nov 5, 2020
Publication date	Jun 27, 2024
Grant date	—

Abstract

The present invention relates to novel peptides having anti-inflammatory and tissue regenerative actions and uses thereof.

First claim

1 . A peptide comprising a sequence represented by the following Formula 1 or 2:

where, X1 is an amino acid classified as a nonpolar, basic, or polar amino acid;
X2 is Ser or absent;
X3 is Ile or absent;
X4 is Lys or absent;
X5 is Gly or absent;
X6 is Ala or absent; and
X7 is Tyr or absent,

where X1 is Ala or absent;
X2 is Val or absent;
X3 is Ser or absent;
X4 is Ser or absent;
X5 is Ile or absent; and
X6 is an amino acid classified as a nonpolar, acidic, basic, or polar amino acid or absent.

2 . The peptide according to claim 1 , wherein the peptide comprises a sequence represented by the following Formula 1 or 2:

where X1 is Val, Gln, Gly, or Ile;
X2 is Ser or absent;
X3 is Ile or absent;
X4 is Lys or absent;
X5 is Gly or absent;
X6 is Ala or absent; and
X7 is Tyr or absent,

where X1 is Ala or absent;
X2 is Val or absent;
X3 is Ser or absent;
X4 is Ser or absent;
X5 is Ile or absent; and
X6 is Lys, Ala, Arg, Ile, Ser, Val, or absent.

3 . The peptide according to claim 1 , wherein the peptide comprises any one of amino acid sequences of SEQ ID NOs: 1 to 15.

4 . A pharmaceutical composition for preventing or treating an inflammatory disease, the pharmaceutical composition comprising the peptide according to claim 1 .

5 . The pharmaceutical composition for preventing or treating an inflammatory disease according to claim 4 , wherein the inflammatory disease is selected from the group consisting of arthritis, metabolic diseases, hepatitis, enteritis, gastritis, gastric ulcer, esophagitis, dermatitis, encephalitis, depression, anxiety disorder, cognitive disorder, memory disorder, degenerative brain disease, and developmental disability.

6 . A composition for tissue regeneration comprising the peptide according to claim 1 .

7 . The composition for tissue regeneration according to claim 6 , wherein the tissue is selected from skin, muscle, hair, hair follicles, or hair roots.

8 . The composition for tissue regeneration according to claim 6 , wherein the tissue regeneration is selected from skin regeneration, muscle tissue regeneration, wound healing, muscle strength enhancement, hair loss prevention, hair growth promotion, trichogen promotion, damaged hair improvement, or hair regeneration.

9 . A composition for preventing or improving an inflammatory disease, the composition comprising the peptide according to claim 1 , wherein
the composition is a health functional food, feed, veterinary medicine, quasi-drug, or cosmetic composition.

10 . A composition for tissue regeneration comprising the peptide according to claim 1 , wherein
the composition is a health functional food, feed, veterinary medicine, quasi-drug, or cosmetic composition.

11 . A pharmaceutical composition for preventing or treating a tissue damage-related disease, the pharmaceutical composition comprising the peptide according to claim 1 .

12 . A method for preventing or treating an inflammatory disease, the method comprising administering the peptide according to claim 1 to a subject.

13 . A tissue regeneration method comprising administering the peptide according to claim 1 to a subject.

14 . A polynucleotide encoding the peptide according to claim 1 .

15 . A vector comprising the polynucleotide according to claim 14 .

16 . A pharmaceutical composition for preventing or treating an inflammatory disease, the pharmaceutical composition comprising the peptide according to claim 2 .

17 . A pharmaceutical composition for preventing or treating an inflammatory disease, the pharmaceutical composition comprising the peptide according to claim 3 .

Assignees

• Korea Res Inst Bioscience & Biotechnology

Inventors

• Lee Chul-Ho
• Kim Yong-Hoon
• Kim Kyoung-Shim
• Noh Jung-Ran
• Lee Kyeong-Ryooon
• Kim Byoung-Chan
• Choi Dong-Hee
• Kim Jae-Hoon
• Kang Eun-Jung
• Go Jun
• Choi Young-Keun
• Lee In-Bok
• Seo Yun-Jung
• Choi Jung-Hyeon
• Chang Dong-Ho
• Park Hye-Yeon
• Park Jung-Ho

Classifications

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• C07K7/06 Primary

  having 5 to 11 amino acids · CPC title

• A61P25/22

  Anxiolytics · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P1/16

  for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics · CPC title