Sensory threshold and/or adaptation for neurological therapy screening and/or parameter selection, and associated systems and methods

Patent metadata

Field	Value
Publication number	US-2023347150-A1
Application number	US-202318107498-A
Country	US
Kind code	A1
Filing date	Feb 8, 2023
Priority date	Jan 17, 2019
Publication date	Nov 2, 2023
Grant date	—

Abstract

Systems and methods for using sensory threshold and/or adaptation for neurological therapy screening and/or parameter selection. A representative method for establishing a treatment regimen for a patient includes: in response to a first indication of a characteristic of the patient's sensory response to an electrical stimulus, providing a second indication indicating suitability of an electrical signal for delivery to the patient to address a patient condition, wherein the electrical signal has a frequency in a frequency range from 1.2 kHz to 100 kHz.

First claim

1 - 64 . (canceled)

65 . A method of treating a patient, the method comprising:
determining a level of adaptation of a patient's sensory response to a suprathreshold electrical stimulus for each of a plurality of different electrodes and/or electrode combinations; based on the determined levels of adaptation, selecting a specific electrode and/or electrode combination of the plurality of different electrodes and/or electrode combinations for delivery of an electrical signal to the patient to address a patient condition; and programming a signal generator to generate and deliver the electrical signal to the patient via the selected specific electrode and/or electrode combination.

66 . The method of claim 65 , further comprising delivering the electrical signal to the patient via the selected specific electrode and/or electrode combination to address the patient condition.

67 . The method of claim 65 wherein the different electrodes and/or electrode combinations have different locations within the patient.

68 . The method of claim 65 wherein determining the level of adaptation at each of the plurality of different electrodes and/or electrode combinations includes determining a level of adaptation for two or more different biopole pairs of electrodes.

69 . The method of claim 65 wherein selecting the specific electrode and/or electrode combination based on the determined levels of adaptation includes:
comparing the levels of adaptation determined for each of the different electrodes and/or electrode combinations; and
selecting the specific electrode and/or electrode combination based on the comparison.

70 . The method of claim 69 wherein selecting the specific electrode and/or electrode combination based on the comparison includes selecting the specific electrode and/or electrode combination associated with the largest level of adaptation.

71 . The method of claim 65 wherein the electrical signal is a paresthesia-free electrical signal.

72 . The method of claim 65 wherein the electrical signal has a frequency within a frequency range of from about 1.2 kHz to about 100 kHz.

73 . A method of treating a patient, the method comprising:
receiving a first indication of a level of adaptation of a patient's sensory response to a suprathreshold electrical stimulus for each of a plurality of different electrodes and/or electrode combinations; based on the first indication, providing a second indication identifying a specific electrode and/or electrode combination for delivery of an electrical signal to address a patient condition; and based on the second indication, programming a signal generator to generate and deliver the electrical signal to the patient via the identified specific electrode and/or electrode combination.

74 . The method of claim 73 , further comprising delivering the electrical signal to the patient via the identified electrode and/or electrode combination.

75 . The method of claim 73 wherein the identified electrode and/or electrode combination includes a bipole electrode pair.

76 . The method of claim 73 wherein providing the second indication based on the first indication includes analyzing the first indication to determine which electrode and/or electrode combination is associated with the largest level of adaptation to the suprathreshold electrical stimulus.

77 . The method of claim 73 wherein the electrical signal does not induce paresthesia in the patient.

78 . The method of claim 73 wherein the electrical signal has a frequency in a frequency range of from about 1.2 kHz to about 100 kHz.

79 . The method of claim 73 wherein the patient condition includes pain.

80 . The method of claim 73 wherein the different electrodes and/or electrode combinations are implanted at different locations within the patient.

81 . A system for treating a patient, the system comprising:
a machine-readable medium having first instructions and second instructions, wherein the first instructions, when executed:
receive a first indication of a level of adaptation of a patient's sensory response to a suprathreshold electrical stimulus for each of a plurality of different electrodes and/or electrode combinations, and
based on the first indication, provide a second indication identifying a specific electrode and/or electrode combination for delivery of an electrical signal to address a patient condition, and
wherein the second instructions, when executed, cause the electrical signal to be delivered to the patient via the identified specific electrode and/or electrode combination.

82 . The system of claim 81 wherein the operation of providing the second indication based on the first indication includes:
comparing the levels of adaptation for each of the different electrodes and/or electrode combinations; and
identifying the specific electrode and/or electrode combination based on the comparison.

83 . The system of claim 82 wherein identifying the specific electrode and/or electrode combination based on the comparison includes identifying the specific electrode and/or electrode combination associated with the largest level of adaptation.

84 . The system of claim 81 wherein the electrical signal is a paresthesia-free electrical signal and has a frequency within a frequency range of from about 1.2 kHz to about 100 kHz.

Assignees

• Nevro Corp

Inventors

• Lee Dongchul

Classifications

• A61N1/36071 Primary

  Pain · CPC title

• A61N1/36021

  for treatment of pain · CPC title

• G16H40/60

  for the operation of medical equipment or devices · CPC title

• A61N1/3615

  Intensity · CPC title

• A61N1/37264

  Changing the program; Upgrading firmware · CPC title