Methods And Systems For High-Throughput Blood Component Collection

Patent metadata

Field	Value
Publication number	US-2023166021-A1
Application number	US-202318103035-A
Country	US
Kind code	A1
Filing date	Jan 30, 2023
Priority date	Apr 21, 2017
Publication date	Jun 1, 2023
Grant date	—

Abstract

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

First claim

What is claimed is:

1 . A soft cassette comprising:
a housing having a first port and a second port; a first flowpath defined by the housing and configured to permit fluid flow therein and to selectively fluidly connect the first port to the second port; a second flowpath defined by the housing and configured to permit fluid to flow therein and to selectively fluidly connect the first port to the second port; and at least one valve controlling fluid flow through at least one of the first flowpath and the second flowpath.

2 . The soft cassette of claim 1 , wherein the at least one valve includes at least one magnet.

3 . The soft cassette of claim 1 , wherein the at least one valve is a first fluid control valve disposed adjacent to the first port.

4 . The soft cassette of claim 1 , wherein the at least one valve is a second fluid control valve disposed adjacent an inlet to the first flowpath.

5 . The soft cassette of claim 1 , wherein the at least one valve is a third fluid control valve disposed adjacent an inlet to the second flowpath.

6 . The soft cassette of claim 5 , wherein the third fluid control valve is a draw valve.

7 . The soft cassette of claim 1 , wherein the at least one valve includes one or more of:
a first fluid control valve disposed adjacent to the first port; a second fluid control valve disposed adjacent to a first inlet to the first flowpath; or a third fluid control valve disposed adjacent to a second inlet to the second flowpath.

8 . The soft cassette of claim 7 , wherein the at least one valve is configured to have a first operational mode of being fully open and a second operational mode of being fully closed.

9 . The soft cassette of claim 7 , wherein the at least one valve is configured to have a first operational mode of being partially open and a second operational mode of being fully closed.

10 . The soft cassette of claim 1 , wherein the at least one valve is selected from the group consisting of: a solenoid valve, a linearly actuated valve, a pinch valve, a clamp valve, a tubing valve, other actuatable valve, and combinations thereof.

11 . The soft cassette of claim 1 , wherein the housing is a flexible housing.

12 . The soft cassette of claim 1 , wherein the housing includes a material selected from the group consisting of polyvinyl chloride (PVC), plasticized-PVC, polyethylene, ethylene with vinyl acetate (EVA), rubber, silicone, thermoplastics, thermoplastic elastomers, copolymers, and combinations thereof.

13 . The soft cassette of claim 12 , wherein the housing is manufactured by a process selected from the group consisting of: molding, rotomolding, casting, injection molding, or combinations thereof.

14 . The soft cassette of claim 1 , wherein the second flowpath includes an inlet and an outlet and the second flowpath is a loop where the inlet is fluidly connected to the first flowpath and the outlet is fluidly connected to the first flowpath.

15 . The soft cassette of claim 1 further comprising at least one sensor that includes at least one magnet.

16 . The soft cassette of claim 1 further comprising at least one sensor that includes one or more of an ultrasonic detector, a pressure sensor, and a magnetic position sensor.

17 . The soft cassette of claim 1 , wherein the first flowpath is a direct flow lumen extending between the first port and the second port.

18 . The soft cassette of claim 17 , wherein the second flowpath is a bypass flow lumen extending between the first port and the second port.

19 . The soft cassette of claim 18 , wherein the bypass flow lumen is fluidly connected to a portion of the direct flow lumen adjacent to the first port and a portion of the direct flow lumen adjacent to the second port.

20 . The soft cassette of claim 19 , wherein the bypass flow lumen extends from the direct flow lumen adjacent to the first port, along a first bypass branch, through a sensor, to a second bypass branch, to the direct flow lumen adjacent to the second port.

21 . The soft cassette of claim 19 , wherein the bypass flow lumen extends from the direct flow lumen adjacent to the first port, along a first bypass branch, through a pressure diaphragm, to a second bypass branch, to the direct flow lumen adjacent to the second port.

22 . The soft cassette of claim 17 , wherein the direct flow lumen extends along a first section adjacent the first port, through a chamber, and along a second section adjacent the second port.

23 . The soft cassette of claim 1 , wherein the first flowpath defines a chamber.

24 . The soft cassette of claim 23 , wherein the chamber is a drip chamber.

25 . A soft cassette comprising:
a housing having a first port and a second port; a first flowpath defined by the housing and configured to permit fluid to flow therein and to selectively fluidly connect the first port to the second port; a chamber disposed in the first flowpath for selectively collecting fluid; a second flowpath defined by the housing and configured to permit fluid flow therein and to selectively fluidly connect the first port to the second port; at least one valve controlling fluid flow through at least one of the first flowpath and the second flowpath; and at least one sensor.

26 . The soft cassette of claim 25 , wherein the at least one sensor includes at least one magnet.

27 . The soft cassette of claim 25 , wherein the at least one sensor that includes one or more of an ultrasonic detector, pressure sensor, and magnetic position sensor.

28 . The soft cassette of claim 25 , wherein the at least one valve is a first fluid control valve disposed adjacent to the first port.

29 . The soft cassette of claim 25 , wherein the at least one valve is a second fluid control valve disposed adjacent an inlet to the first flowpath.

30 . The soft cassette of claim 25 , wherein the at least one valve is a third fluid control valve disposed adjacent an inlet to the second flowpath.

31 . The soft cassette of claim 30 , wherein the third fluid control valve is a draw valve.

32 . The soft cassette of claim 25 , wherein the at least one valve includes one or more of:
a first fluid control valve disposed adjacent to the first port; a second fluid control valve disposed adjacent to a first inlet to the first flowpath; or a third fluid control valve disposed adjacent to a second inlet to the second flowpath.

33 . The soft cassette of claim 32 , wherein the at least one valve is configured to have a first operational mode of being fully open and a second operational mode of being fully closed.

34 . The soft cassette of claim 32 , wherein the at least one valve is configured to have a first operational mode of being partially open and a second operational mode of being fully closed.

35 . The soft cassette of claim 25 , wherein the at least one valve is selected from the group consisting of: a solenoid valve, a linearly actuated valve, a pinch valve, a clamp valve, a tubing valve, other actuatable valve, and combinations thereof.

36 . The soft cassette of claim 25 , wherein the housing is a flexible housing.

37 . The soft cassette of claim 25 , wherein the housing includes a ma

Assignees

• Terumo Bct Inc

Inventors

• Felt Thomas J
• Hlavinka Dennis J
• Holmes Brian M

Classifications

• A61M2205/123

  with incorporated reservoirs · CPC title

• A61M1/3696 Primary

  with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation · CPC title

• A61M1/024

  Means for controlling the quantity of transfused blood, e.g. by weighing the container and automatic stopping of the transfusion after reaching a determined amount · CPC title

• A61M2202/0415

  Plasma · CPC title

• A61M1/3496

  Plasmapheresis; Leucopheresis; Lymphopheresis (A61M1/3472 takes precedence) · CPC title