Fluid control and bypass features for an apheresis system

Patent metadata

Field	Value
Publication number	US-11103630-B2
Application number	US-201815959025-A
Country	US
Kind code	B2
Filing date	Apr 20, 2018
Priority date	Apr 21, 2017
Publication date	Aug 31, 2021
Grant date	Aug 31, 2021

Abstract

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

First claim

What is claimed is:

1. A blood component collection set, the blood component collection set comprising:
a centrifuge to separate blood components from whole blood;
a cassette inlet tubing fluidly connected to a donor;
a loop inlet tubing fluidly connected to the centrifuge;
a cassette comprising:
a first cassette port fluidly connected to the cassette inlet tubing;
a second cassette port fluidly connected to the loop inlet tubing;
a direct flow lumen fluidly connected to the first cassette port and the second cassette port;
a drip chamber inter-disposed in the direct flow lumen such that the fluid passing through the direct flow lumen passes through the drip chamber; and
a fluid flow bypass path both fluidly connected to the direct flow lumen adjacent the first cassette port and between the first cassette port and the drip chamber and fluidly connected to the direct flow lumen adjacent the second cassette port and between the second cassette port and the drip chamber, such that fluid flowing through the fluid flow bypass path bypasses the drip chamber.

2. The blood component collection set of claim 1 , wherein the fluid flow bypass path comprises:
a first bypass branch fluidly connected to the direct flow lumen adjacent the first cassette port;
a second bypass branch fluidly connected to the direct flow lumen adjacent the second cassette port; and
a fluid pressure annulus disposed between and fluidly connected to the first bypass branch and the second bypass branch.

3. The blood component collection set of claim 2 , wherein the direct flow lumen comprises a first compliant region, disposed between a first connection with the first bypass branch and the drip chamber, that allows a first fluid control valve to occlude the direct flow lumen, wherein the direct flow lumen comprises a second compliant region, disposed between a second connection with the second bypass branch and the drip chamber, that allows a second fluid control valve to occlude the direct flow lumen, and wherein the direct flow lumen comprises a third compliant region, disposed in the first bypass branch, that allows a draw fluid control valve to occlude the first bypass branch.

4. The blood component collection set of claim 3 , wherein, when drawing fluid from the donor:
the first fluid control valve and the second fluid flow control valve are closed and occlude the direct flow lumen; and
the draw fluid control valve is open and allows whole blood to pass through the fluid flow bypass path.

5. The blood component collection set of claim 4 , wherein, when sending fluid to the donor:
the first fluid control valve and the second fluid flow control valve are open and allow fluid to pass through the direct flow lumen; and
the draw fluid control valve is closed and occludes the fluid flow bypass path.

6. The blood component collection set of claim 5 , wherein, when drawing fluid from the donor in a subsequent draw, a portion of the fluid previously sent to the donor through the direct flow lumen is maintained in the drip chamber when the fluid passes through the fluid flow bypass path.

7. A method for moving fluids through a cassette comprising:
providing a cassette, the cassette comprising:
a first cassette port fluidly connected to a cassette inlet tubing;
a second cassette port fluidly connected to a loop inlet tubing;
a direct flow lumen fluidly connected to the first cassette port and the second cassette port;
a drip chamber inter-disposed in the direct flow lumen such that the fluid passing through the direct flow lumen passes through the drip chamber; and
a fluid flow bypass path both fluidly connected to the direct flow lumen adjacent the first cassette port and between the first cassette port and the drip chamber and fluidly connected to the direct flow lumen adjacent the second cassette port and between the second cassette port and the drip chamber, such that fluid flowing through the fluid flow bypass path bypasses the drip chamber;
when drawing whole blood from a donor:
receiving whole blood from the cassette inlet tubing at a first cassette port fluidly connected to the cassette inlet tubing;
moving the whole blood through the fluid flow bypass path to the second cassette port;
preventing whole blood from moving through the direct lumen;

when returning red blood cells to the donor:
receiving red blood cells from the loop inlet tubing at a second cassette port fluidly connected to the loop inlet tubing;
moving the red blood cells through the direct flow lumen and the drip chamber to the first cassette port; and
preventing red blood cells from moving through the fluid flow bypass path.

8. The method of claim 7 , wherein, when drawing fluid from the donor in a subsequent draw, a portion of the fluid previously sent to the donor through the direct flow lumen, when returning red blood cells to the donor, is maintained in the drip chamber when the whole blood again passes through the fluid flow bypass path.

Assignees

• Terumo Bct Inc

Inventors

• Holmes Brian M
• Felt Thomas J
• Polodna Taylor

Classifications

• A61M1/36222

  Details related to the interface between cassette and machine · CPC title

• A61M1/362261

  at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil · CPC title

• A61M1/362265

  Details of valves · CPC title

• A61M1/362262

  Details of incorporated reservoirs · CPC title

• A61M1/36224

  with sensing means or components thereof · CPC title