Roughly cylindrical sample containers having multiple reservoirs therein and being adapted for acoustic ejections

Patent metadata

Field	Value
Publication number	US-2022297118-A1
Application number	US-202217824759-A
Country	US
Kind code	A1
Filing date	May 25, 2022
Priority date	Jan 15, 2014
Publication date	Sep 22, 2022
Grant date	—

Abstract

Provided herein is generally tubular container, preferably including a plurality of reservoirs defined therein. The container can be adapted for acoustic ejection of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs. Alternatively, the container can be adapted for extraction of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs using a non-acoustic liquid handling method.

First claim

1 - 3 . (canceled)

4 . A system for acoustically extracting fluid from a plurality of reservoirs, the system comprising:
a generally tubular container comprising a plurality of reservoirs formed therein, the container having a major axis with each of the reservoirs extending along at least a portion of the container in a direction parallel to the major axis and terminating at an opening to allow acoustic ejection of a fluid therefrom, wherein each reservoir in the plurality of reservoirs is isolated from other reservoirs in the plurality of reservoirs; and an acoustic radiation ejector to generate, direct, and focus an acoustic beam toward a selected reservoir in the plurality of reservoirs.

5 . The system of claim 4 , wherein a first reservoir of the plurality of reservoirs comprises a first compound and a second reservoir of the plurality of reservoirs comprises a second compound.

6 . The system of claim 5 , wherein the first compound and the second compound are different.

7 . The system of claim 5 , wherein the first compound and the second compound are the same and present at different concentrations in the first reservoir and the second reservoir.

8 . The system of claim 4 , wherein at least two reservoirs in the plurality of reservoirs have different volumes.

9 . The system of claim 4 , wherein each reservoir in the plurality of reservoirs comprises a different sample fluid.

10 . The system of claim 9 , wherein each reservoir in the plurality of reservoirs comprises a sample from a different patient.

11 . The system of claim 9 , wherein each reservoir in the plurality of reservoirs comprises a different fraction of a sample from the same patient.

12 . The system of claim 4 , wherein each reservoir includes a bottom that is acoustically distinguishable from the bottom of each other reservoir.

13 . The system of claim 12 , wherein each reservoir includes a bottom having a thickness that is different from the bottom of each other reservoir.

14 . The system of claim 1 , further including a motion system for positioning the acoustic radiation ejector and the selected reservoir relative to each other so as to be acoustically coupled and thereby facilitate acoustic ejection of a fluid from the selected reservoir.

15 . The system of claim 1 , wherein each reservoir includes a bottom, the bottom of at least one of the reservoirs including an acoustically distinguishable difference in thickness from the bottom of at least one other of the reservoirs.

Assignees

• Labcyte Inc

Inventors

• Ellson Richard N

Classifications

• B01L3/0268

  using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries · CPC title

• B01L3/50855

  using modular assemblies of strips or of individual wells · CPC title

• B01J2219/00362

  Acoustic nozzles · CPC title

• B01L2400/0436

  acoustic forces, e.g. surface acoustic waves [SAW] · CPC title

• B01J2219/00319

  the blocks being mounted in stacked arrangements · CPC title