Roughly cylindrical sample containers having multiple reservoirs therein and being adapted for acoustic ejections

Patent metadata

Field	Value
Publication number	US-9861987-B2
Application number	US-201514595063-A
Country	US
Kind code	B2
Filing date	Jan 12, 2015
Priority date	Jan 15, 2014
Publication date	Jan 9, 2018
Grant date	Jan 9, 2018

Abstract

Provided herein is generally tubular container, preferably including a plurality of reservoirs defined therein. The container can be adapted for acoustic ejection of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs. Alternatively, the container can be adapted for extraction of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs using a non-acoustic liquid handling method.

First claim

What is claimed:

1. A generally tubular container including a plurality of reservoirs defined therein,
the container including a major axis, each of the reservoirs extending along at least a portion of the container in a direction parallel to the major axis.

2. The generally tubular container of claim 1 , being adapted for acoustic ejection of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs.

3. The generally tubular container of claim 2 , wherein a plurality of fluids are respectively disposed with the reservoirs of the plurality of reservoirs, and wherein the plurality of fluids are selected from a group consisting of: different samples from a patient, different fractions of a sample from a patient, and different concentrations of a compound, chemical, or drug.

4. The generally tubular container of claim 3 , wherein the reservoirs isolate the plurality of fluids from one another.

5. The generally tubular container of claim 2 , each reservoir including a bottom, the bottom of at least one of the reservoirs including an acoustically distinguishable difference in thickness from the bottom of at least one other of the reservoirs.

6. The generally tubular container of claim 1 , being adapted for extraction of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs using a non-acoustic liquid handling method.

7. The generally tabular container of claim 6 , wherein the non-acoustic liquid handling method is based on an insertion of a solid transfer device into one of the reservoirs.

8. The generally tubular container of claim 7 , wherein the solid transfer device includes a pipette, capillary, or pin tool.

9. The generally tubular container of claim 1 , the plurality of reservoirs including three or more reservoirs.

10. The generally tubular container of claim 1 , a cross-section of the generally tubular container being generally circular.

11. The generally tubular container of claim 1 , wherein the container is tapered along the major axis.

12. A generally tubular container including a plurality of reservoirs defined therein, wherein one or more of the reservoirs has a volume that is different than a volume of at least one other of the reservoirs.

13. The generally tubular container of claim 12 , wherein one or more of the reservoirs has a volume that is at least 10% larger than that of another of the reservoirs.

14. The generally tubular container of claim 12 , including a major axis, each of the reservoirs extending along at least a portion of the container in a direction parallel to the major axis.

15. A stacked plurality of generally tubular containers, at least one of the generally tubular containers including a plurality of reservoirs defined therein, the stacked plurality being retrievable as a group.

16. The stacked plurality of generally tubular containers of claim 15 , the at least one of the generally tubular containers being adapted for acoustic ejection of a plurality of fluids respectively disposed within the reservoirs of the plurality of reservoirs.

17. A method comprising extracting a fluid from a generally tubular container including a plurality of reservoirs defined therein,
wherein a plurality of fluids are respectively disposed within the reservoirs of the plurality of reservoirs, and
wherein the plurality of fluids are selected from a group consisting of: different samples from a patient, different fractions of a sample from a patient, and different concentrations of a compound, chemical, or drug.

18. The method of claim 17 , wherein the extracting comprises acoustically ejecting the fluid.

19. The method of claim 17 , wherein extracting a fluid disposed within at least one of the reservoirs of the plurality of reservoirs comprises using a non-acoustic liquid handling method.

20. The method of claim 19 , wherein the non-acoustic liquid handling method is based on an insertion of a solid transfer device into one of the reservoirs.

21. The method of claim 20 , wherein the solid transfer device includes a pipette, capillary, or pin tool.

22. The method of claim 17 , the plurality of reservoirs including three or more reservoirs.

23. The method of claim 17 , a cross-section of the generally tubular container being generally circular.

24. A method comprising extracting a fluid from a generally tubular container including a plurality of reservoirs defined therein, wherein one or more of the reservoirs has a volume that is different than a volume of at least one other of the reservoirs.

25. The method of claim 24 wherein one or more of the reservoirs has a volume that is at least 10% larger than that of another of the reservoirs.

26. A method comprising extracting a fluid from a generally tubular container including a plurality of reservoirs defined therein, each reservoir including a bottom, the bottom of at least one of the reservoirs including an acoustically distinguishable difference in thickness from the bottom of at least one other of the reservoirs.

27. A method comprising extracting a fluid from a generally tubular container including a plurality of reservoirs defined therein, further comprising acoustically distinguishing at least one of the reservoirs from at least one other of the reservoirs.

28. A method comprising extracting a fluid from a generally tubular container including a plurality of reservoirs defined therein, the generally tubular container including a major axis, each of the reservoirs extending along at least a portion of the container in a direction parallel to the major axis.

29. The method of claim 28 , wherein the fluid is disposed within at least one of the reservoirs of the plurality of reservoirs.

30. The method of claim 29 , wherein a plurality of fluids are respectively disposed with the reservoirs of the plurality of reservoirs, and wherein the plurality of fluids are selected from a group consisting of: different samples from a patient, different fractions of a sample from a patient, and different concentrations of a compound, chemical, or drug.

31. The method of claim 30 , wherein the reservoirs isolate the plurality of fluids from one another.

32. A method comprising extracting a fluid from a generally tubular container including a plurality of reservoirs defined therein, wherein the container is tapered along a major axis.

33. A method comprising retrieving, as a group, a stacked plurality of generally tubular containers, at least one of the generally tubular containers including a plurality of reservoirs defined therein and being adapted for acoustic ejection of at least one fluid disposed within at least one of the reservoirs of the plurality of reservoirs.

Assignees

• Labcyte Inc

Inventors

• Ellson Richard N

Classifications

• B01L3/50855

  using modular assemblies of strips or of individual wells · CPC title

• B01L3/0268

  using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries · CPC title

• B01J2219/00313

  the reactor vessels being formed by arrays of wells in blocks · CPC title

• B01L3/0244

  using pins · CPC title

• B01J2219/00319

  the blocks being mounted in stacked arrangements · CPC title