Lactic acid adsorbent and method for removing lactic acid

Patent metadata

Field	Value
Publication number	US-2022266220-A1
Application number	US-202217741871-A
Country	US
Kind code	A1
Filing date	May 11, 2022
Priority date	Nov 13, 2019
Publication date	Aug 25, 2022
Grant date	—

Abstract

A lactic acid adsorbent includes a layered double hydroxide that contains multiple metal hydroxide layers and also contains anions and water molecules held between the metal hydroxide layers. The anions include (i) an amino acid such as glutamine, (ii) a dipeptide constituted by one or two kinds of amino acids such as glutamine, (iii) a vitamin such as ascorbic acid 2-phosphate, (iv) a pH buffer such as MES, (v) a glucose metabolite such as pyruvic acid, or (vi) inorganic ions selected from a group including NO3− and Cl−.

First claim

What is claimed is:

1 . A lactic acid adsorbent including a layered double hydroxide that contains a plurality of metal hydroxide layers and also contains anions and water molecules held between the metal hydroxide layers,
the anions including at least one of:
(i) at least one amino acid selected from a group including glutamic acid, aspartic acid, glycine, alanine, valine, leucine, isoleucine, serine, threonine, cysteine, methionine, asparagine, glutamine, phenylalanine, tyrosine, tryptophan, and proline;
(ii) a dipeptide constituted by one or two kinds of amino acids selected from the group;
(iii) at least one vitamin selected from a group including ascorbic acid 2-phosphate and folic acid;
(iv) at least one pH buffer selected from a group including MES, Bis-Tris, ADA, PIPES, ACES, MOPSO, BES, MOPS, TES, HEPES, DIPSO, TAPSO, and POPSO;
(v) at least one glucose metabolite selected from a group including pyruvic acid, citric acid, ketoglutaric acid, succinic acid, oxaloacetic acid, and fumaric acid; or
(vi) inorganic ions of at least one kind selected from a group including NO 3 − and Cl − , and
the lactic acid adsorbent being brought into contact with a solution that contains lactic acid and glucose and adsorbing lactic acid in the solution.

2 . The lactic acid adsorbent according to claim 1 , wherein
the metal hydroxide layers contain divalent metal ions M 2+ and trivalent metal ions M 3+ , and the divalent metal ions M 2+ are Mg 2+ or Ca 2+ .

3 . The lactic acid adsorbent according to claim 1 , wherein the solution is a culture solution for cells or microorganisms.

4 . A method for removing lactic acid, the method comprising bringing the lactic acid adsorbent according to claim 1 into contact with lactic acid.

Assignees

• Nikkiso Co Ltd
• Univ Tohoku

Inventors

• Yoshioka Toshiaki
• Kameda Tomohito
• Kitagawa Fumihiko
• Jimbo Yoichi
• Kondo Masayuki

Classifications

• B01J20/2803

  Sorbents comprising a binder, e.g. for forming aggregated, agglomerated or granulated products · CPC title

• B01J20/041 Primary

  Oxides or hydroxides · CPC title

• C01G53/82

  Compounds containing nickel, with or without oxygen or hydrogen, and containing two or more other elements · CPC title

• B01J20/24 Primary

  Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives · CPC title

• B01J20/043

  Carbonates or bicarbonates, e.g. limestone, dolomite, aragonite · CPC title