Aloe Based Compositions Comprising Polysaccharides and Polyphenols for Regulation of Homeostasis of Immunity

Patent metadata

Field	Value
Publication number	US-2022016196-A1
Application number	US-202117370200-A
Country	US
Kind code	A1
Filing date	Jul 8, 2021
Priority date	Jul 9, 2020
Publication date	Jan 20, 2022
Grant date	—

Abstract

Compositions used and methods are disclosed for regulation of immunity homeostasis including a combination of an Aloe extract enriched for one or more polysaccharides; a Poria extract enriched for one or more polysaccharides; and a Rosemary extract enriched for one or more polyphenolic compounds. Compositions for maintenance of immunity homeostasis by regulating HMGB1, comprising a combination of one or more polysaccharides and one or more polyphenolic compounds are disclosed. Methods for treating, managing, promoting regulation of immunity homeostasis in a mammal are disclosed that include administering an effective amount of a composition from 0.01 mg/kg to 500 mg/kg body weight of the mammal.

First claim

1 . A composition for regulation of immunity homeostasis, comprising a combination of an Aloe extract enriched for one or more polysaccharides; a Poria extract enriched for one or more polysaccharides; and a Rosemary extract enriched for one or more polyphenolic compounds.

2 . The composition of claim 1 , wherein the Aloe extract, or Poria extract or Rosemary extract in the composition is in a range of 1%-98% by weight of each extract with the optimized weight ratio of Aloe:Poria:Rosemary (APR) at 3:2:1 (50%:33.3%:16.7%) or 1:1:1 (33.3%:33.3%:33.3%) or 3:6:1 (30%:60%:10%).

3 . The composition of claim 1 , wherein the Aloe extract is whole leaf gel or inner leaf gel from Aloe vera or Aloe barbadense, the Poria extract is from mushroom or fruit body of Poria cocos or Wolfiporia extensa, and Rosemary extract is from leaf of Rosmarinus officinalis.

4 . The composition of claim 1 wherein the Aloe extract comprises 0.01% to 99.9% of polysaccharides.

5 . The composition of claim 1 wherein the Poria extract comprises 0.01% to 99.9% of polysaccharides.

6 . The composition of claim 1 wherein the Rosemary extract comprises 0.01% to 99.9% of Rosmarinic acid.

7 . The composition of claim 1 , wherein the one or more polysaccharides from the Aloe extract is an acetylated polysaccharide or acemannan or any combination thereof.

8 . The composition of claim 1 , wherein the one or more polysaccharides from the Poria extract is a beta-glucan or a combination thereof.

9 . The composition of claim 1 , wherein the one or more polysaccharides are enriched from a plant species selected from the group consisting of or a combination thereof Aloe vera, Aloe barbadense, Aloe ferox, Aloe arborescens, Astragalus membranaceus, Ganoderma lucidum, Hordeum vulgare, Agaricus ( A. blazei ) subrufescens, Echinacea purpurea, Echinacea angustifolia, Aconitum Napellus (Monkshood), Sambucus nigra, Poria cocos Wolf, Wolfiporia extensa, Withania somnifera, Bupleurum falcatum, Glycyrrhiza spp, Panax quinquefolium, Panax ginseng C. A. Meyer, Korea red ginseng, Lentinula edodes (shiitake), Inonotus obliquus ( Chaga mushroom), Lentinula edodes, Lycium barbarum, Lycium chinense, Phellinus linteus (fruit body), Trametes versicolor (fruit body), Cyamopsis tetragonolobus Cyamopsis tetragonolobus (guar gum), Trametes versicolor, Cladosiphon okamuranus Tokida, Undaria pinnatifida, mushrooms, seaweeds, yeasts, brown algae, Agave Nectar, brown seaweed, fermentable fiber, cereal, sea cucumber, agave, artichokes, asparagus, leeks, garlic, onions, rye, barley kernels, wheat, pears, apples, guavas, quince, plums, gooseberries, oranges and other citrus fruits.

10 . The composition of claim 1 , wherein the polyphenolic compounds are enriched from a plant species selected from the group consisting of or a combination thereof Melissa officinalis, Momordica balsamina, Mentha piperita, Perilla frutescens, Salvia officinalis, Teucrium scorodonia, Sanicula europaea, Coleus blumei, Thymus spp Hyptis verticillata, Lithospermum erythrorhizon, hornwort Anthoceros agrestis, Piper longum Linn, Coptis chinensis Franch, Angelica sinensis (Oliv.) Diels, Toxicodendron vernicifluum, Glycyrrhiza glabra, Glycyrrhiza uralensis, Curcuma longa, Salvia Rosmarinus, Rosmarinus officinalis, Zingiber officinalis, Polygala tenuifolia, Humulus lupulus, Lonicera Japonica, Salvia officinalis L., Centella asiatica, Boswellia carteri, Mentha longifolia, Picea crassifolia, Citrus nobilis Lour, Citrus aurantium L. Camellia sinensis L. Pueraria mirifica, Pueraria lobata, Glycine max, Capsicum species, Fallopia japonica, tea, tomato, cruciferous vegetables, grapes, blueberries, raspberries, mulberries, apple, chili peppers.

11 . The composition of claim 1 , wherein the polyphenolic compounds comprise Rosmarinic acid, conjugated catechins such as EGCG, ECG, epigallocatechin, oroxylin, Kaempferol, genistein, quercetin, Butein, Luteolin, chrysin, Apigenin, curcumin, resveratrol, capsaicin, glomeratose A, 6-shogaol, gingerol, berberine, Piperine or a combination thereof.

12 . The composition of claim 1 , wherein the polysaccharides and polyphenols are enriched from a plant part or a fungus selected from the group consisting of leaves, bark, trunk, trunk bark, stem, stem bark, twigs, tubers, root, rhizome, root bark, bark surface, young shoots, seed, fruit, fruitbody, mushroom, androecium, gynoecium, calyx, stamen, petal, sepal, carpel (pistil), flower, or any combination thereof.

13 . The composition of claim 1 , wherein the Aloe extract, the Poria extract and the Rosemary extract in the composition are extracted with any suitable solvent, including supercritical fluid of CO 2 , water, methanol, ethanol, acetone, alcohol, a water-mixed solvent or a combination thereof.

14 . The composition of claim 1 , wherein the polysaccharides are enriched individually and/or in combination by solvent precipitation, ultrafiltration, enzyme digestion, column chromatograph with silica gel, XAD, HP20, LH20, C-18, alumina oxide, polyamide, CG161, and size exclusion column resins.

15 . The composition of claim 1 , wherein one or more polyphenols are enriched individually or in combination by solvent partition, precipitation, distillation, evaporation, ultrafiltration, column chromatograph with silica gel, XAD, HP20, LH2O, C-18, alumina oxide, polyamide, size exclusion column and CG161 resins.

16 . The composition of claim 1 , wherein the composition further comprises a pharmaceutically or nutraceutically acceptable active, adjuvant, carrier, diluent, or excipient, and wherein the pharmaceutical or nutraceutical formulation comprises from about 0.1 weight percent (wt %) to about 99.9 wt % of active compounds.

17 . The composition of claim 16 , wherein the active, adjuvant, excipient or carrier comprises Cannabis sativa oil or CBD/THC, turmeric extract or curcumin, terminalia extract, willow bark extract, Devil's claw root extract, cayenne pepper extract or capsaicin, Prickly Ash bark extract, philodendra bark extract, hop extract, Boswellia extract, rose hips extract, green tea extract, Sophora extract, Mentha or Peppermint extract, ginger or black ginger extract, green tea or grape seed polyphenols, Omega-3 or Omega-6 Fatty Acids, fish oil, Krill oil, gamma-linolenic acid, citrus bioflavonoids, Acerola concentrate, astaxanthin, pycnogenol, vitamin C, vitamin D, vitamin E, vitamin K, vitamin B, vitamin A, L-lysine, calcium, manganese, zinc, mineral amino acid chelate(s), amino acid(s), boron and boron glycinate, silica, probiotics, Camphor, Menthol, calcium-based salts, silica, histidine, copper gluconate, CMC, maltodextrin, beta-cyclodextrin, cellulose, dextrose, saline, water, oil, shark and bovine cartilage, or a combination thereof.

18 . The composition of claim 1 , wherein the composition is formulated as a tablet, hard capsule, soft gel capsule, powder, or granule, compressed tablet, pill, gummy, chewing gum, sashay, wafer, bar, or liquid form, tincture, aerial spread, semi solid, semi liquid, solution, emulsion, cream, lotion, ointment, gel base or like form.

19 . A method for treating, managing, promoting regulation of immunity homeostasis in a mammal, comprising administering an effective amount of a composition from 0.01 mg/kg to 500 mg/kg body weight of the mammal.

20 . The method of claim 19 , wherein the composition comprises a combination of an Aloe extract enriched for one or more polysaccharides; a Poria extract enriched for one or

Assignees

• Unigen Inc

Inventors

• Yimam Mesfin
• Jiao Ping
• Horm Teresa
• Brownell Lidia
• Hong Mei
• O'Neal Alexandria
• Jia Qi

Classifications

• A61K36/3486

  Humulus · CPC title

• A61K36/3482

  Cannabis · CPC title

• A61K31/352

  condensed with carbocyclic rings, e.g. methantheline  {(cannabinoids A61K31/658)} · CPC title

• A61K31/05

  Phenols {(cannabinoids A61K31/658)} · CPC title

• A61K36/076

  Poria · CPC title