Compositions and Methods for Treating the Eye

Patent metadata

Field	Value
Publication number	US-2021145909-A1
Application number	US-202017099185-A
Country	US
Kind code	A1
Filing date	Nov 16, 2020
Priority date	Nov 19, 2019
Publication date	May 20, 2021
Grant date	—

Abstract

The present invention relates to compositions comprising one or more compounds and/or extracts which induce, promote and/or improve production/release/delivery/excretion of hyaluronic acid and/or mucin from and/or in the cornea, and methods of using the compositions to treat the eye.

First claim

What is claimed is:

1 . A microemulsion composition for treating the eye comprising:
i) one or more extracts, or sources of extracts, of the genus Pichia ; and ii) an ophthalmologically acceptable carrier wherein the microemulsion droplets or particles have a maximum dimension of less than 1,500 Å.

2 . The composition according to claim 1 , wherein the genus of Pichia is selected from Pichia anomala, Pichia guilhermondii, Pichia norvegensis, Pichia ohmeri and mixtures thereof.

3 . The composition according to claim 2 , wherein the genus of Pichia is Pichia anomala.

4 . The composition of claim 1 , where in the one or more extracts, or sources of extracts, of the genus Pichia are present at a concentration of from about 0.001% to about 100% by weight of the total composition.

5 . The composition of claim 1 , where in the one or more extracts, or sources of extracts, of the genus Pichia are present at a concentration of from about 0.005% to about 95% by weight of the total composition.

6 . The composition of claim 1 , where in the one or more extracts, or sources of extracts, of the genus Pichia are present at a concentration of from about 0.01% to about 90% by weight of the total composition.

7 . The composition according to claim 1 , comprising a permeation enhancer.

8 . The composition of claim 7 wherein the permeation enhancer is present at a concentration of from about 0.01% to about 20% (w/v) of the total composition.

9 . The composition of claim 8 wherein the permeation enhancer is present at a concentration of from about 0.1% to 10% (w/v) of the total composition.

10 . The composition of claim 9 wherein the permeation enhancer is present at a concentration of from about 0.25% to 5% (w/v) of the total composition,

11 . The composition of claim 7 wherein the permeation enhancer is selected from polyoxyethylene, polyoxyethylene ethers of fatty acids, sorbitan monooleate, sorbitan monolaurate, polyoxyethylene monolaurate, polyoxyethylene sorbitan monolaurate, fusidic acid and derivatives thereof, EDTA, disodium EDTA, cholic acid, deoxycholic acid, glycocholic acid, glycodeoxycholic acid, taurocholic acid, taurodeoxycholic acid, sodium cholate, sodium glycocholate, glycocholate, sodium deoxycholate, sodium taurocholate, sodium glycodeoxycholate, sodium taurodeoxycholate, chenodeoxycholic acid, urosdeoxycholic acid, saponins, glycyrrhizic acid, ammonium glycyrrhizide, decamethonium, decamethonium bromide, and dodecyltrimethylammonium bromide or mixtures of any of the above.

12 . The composition of claim 1 wherein the Pichia genus extract comprises oligosaccharides and polysaccharide having a weight average molecular weight of from about 180 to about 800,000 Da.

13 . The composition of claim 1 wherein the Pichia genus extract comprises oligosaccharides and polysaccharide having an average degree of polymerization of from DP 1 to DP 4444.

Assignees

• Johnson & Johnson Consumer Inc

Inventors

• Li Wen-Hwa Ting
• Mahmood Khalid
• Parsa Ramine
• Randhawa Manpreet
• Bai Mingqi
• Holeva Kenneth T

Classifications

• A61K36/064 Primary

  Saccharomycetales, e.g. baker's yeast · CPC title

• A61K47/02

  Inorganic compounds · CPC title

• A61K47/12

  Carboxylic acids; Salts or anhydrides thereof · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title

• A61K47/10

  Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers · CPC title