Organically modified mineral micro-particles, methods of preparing the same and uses thereof

Patent metadata

Field	Value
Publication number	US-2021106681-A1
Application number	US-201917044769-A
Country	US
Kind code	A1
Filing date	Apr 10, 2019
Priority date	Apr 16, 2018
Publication date	Apr 15, 2021
Grant date	—

Abstract

The present invention is situated in the field of mineral micro-particles selected from the list consisting of aluminum hydroxide, aluminum phosphate, amorphous aluminium hydroxyphosphate and calcium phosphate micro-particles. More particularly, the invention provides organically-derivatized mineral micro-particles, uses thereof, and methods of preparing the same.

First claim

1 . A method for preparing organically-derivatized mineral micro-particles which comprises:
a) providing a solution of one or more organic polyphosphates, b) providing mineral micro-particles, c) suspending said mineral micro-particles in said solution of one or more organic polyphosphates, and d) stirring the resulting suspension, wherein said mineral micro-particles are selected from aluminum hydroxide, aluminum phosphate, amorphous aluminum hydroxyphosphate and/or calcium phosphate micro-particles, and wherein said organic polyphosphate is selected from compounds of formula 1A or 1B:

wherein:
n is an integer in the range of 0-5;
m is an integer in the range of 2-10;
R a denotes organic substituents selected from adenosine and other nucleosides, thiamines, carbohydrates and isoprenes; and
R b denotes organic substituents selected from inositols and other cyclitols, and carbohydrates.

2 . The method according to claim 1 , wherein the solution of one or more organic polyphosphates comprises an inositol phosphate selected from inositol bisphosphate (IP2), inositol trisphosphate (IP3), inositol tetraphosphate (IP4), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6).

3 . The method according to claim 1 , wherein said solution of one or more organic polyphosphates comprises inositol hexaphosphate (IP6) or a salt thereof.

4 . The method according to claim 1 , wherein step d) is continued until the zeta-potential of the organically-derivatized mineral micro-particles does not change by more than 10% over a period of 5 minutes, measured by analyzing samples of reaction product isolated with an interval of 5 minutes±10 seconds.

5 . The method according to claim 1 , wherein the mineral micro-particle starting material comprises calcium phosphate micro-particles.

6 . The method according to claim 1 , wherein the mineral micro-particle starting material comprises aluminum.

7 . Organically-derivatized mineral micro-particles obtained by the method according to claim 1 .

8 . Organically-derivatized calcium phosphate micro-particles obtained by the method according to claim 1 .

9 . Organically-derivatized mineral micro-particles according to claim 1 , having a nominal zeta-potential when measured at pH 7.0 in distilled water of at least −35 mV for micro-particles derived from aluminum phosphate or hydroxyphosphate or at least −40 mV for micro-particles derived from calcium phosphate.

10 . Organically-derivatized mineral micro-particles according to claim 7 for use in medicine.

11 . Organically-derivatized mineral micro-particles according to claim 7 for use as biomolecules delivery or adsorption systems.

12 . Organically-derivatized mineral micro-particles according to claim 11 for use as a biomolecules delivery systems, wherein said biomolecules delivery system is a vaccine adjuvant.

13 . Organically-derivatized mineral micro-particles according to claim 12 for use as vaccine adjuvants, in vaccines.

14 . Organically-derivatized mineral micro-particles according to claim 11 for use in blood fractionation.

15 . A biomolecules delivery or adsorption system comprising the organically-derivatized mineral micro-particles according to claim 7 .

16 . The biomolecules delivery or adsorption system according to claim 15 , wherein the biomolecules delivery system is a vaccine adjuvant.

Assignees

• Croda Int Plc

Inventors

• Duroux Laurent
• Lindblad Erik

Classifications

• C01B25/327

  After-treatment · CPC title

• A61K2039/55505

  Inorganic adjuvants · CPC title

• C01B25/36 Primary

  Aluminium phosphates · CPC title

• A61K39/39 Primary

  characterised by the immunostimulating additives, e.g. chemical adjuvants · CPC title

• A61K2039/55511

  Organic adjuvants · CPC title