Method for producing nonaqueous composition for external use on skin

Patent metadata

Field	Value
Publication number	US-2020306148-A1
Application number	US-201816753396-A
Country	US
Kind code	A1
Filing date	Oct 5, 2018
Priority date	Oct 6, 2017
Publication date	Oct 1, 2020
Grant date	—

Abstract

A method for producing a nonaqueous composition for external use on the skin including a strongly hydrophilic amphiphilic solid active ingredient-surfactant complex dissolved or dispersed in an oil phase, the method including the steps of: dissolving a surfactant in an oil phase to obtain a surfactant solution; mixing the obtained surfactant solution with a strongly hydrophilic amphiphilic solid active ingredient to obtain a suspension; and allowing the obtained suspension to stand still to obtain a transparent composition. Unlike conventional methods for preparing S/O formulations, the strongly hydrophilic amphiphilic solid active ingredient can be solubilized in an oil phase without the process of emulsification and freeze drying.

First claim

1 - 9 . (canceled)

10 . A method for producing a nonaqueous composition for external use on the skin comprising a strongly hydrophilic amphiphilic solid active ingredient-surfactant complex dissolved or dispersed in an oil phase, the method comprising the steps of:
(a) dissolving a surfactant in an oil phase to obtain a surfactant solution; (b) mixing the surfactant solution obtained in the step (a) with a strongly hydrophilic amphiphilic solid active ingredient to obtain a suspension; and (c) allowing the suspension obtained in the step (b) to stand still to obtain a transparent composition.

11 . The production method according to claim 10 , wherein in the step (b), the mixing is performed using a high-speed stirrer or an ultrasonic stirrer.

12 . The production method according to claim 10 , wherein in the nonaqueous composition for external use on the skin, the strongly hydrophilic amphiphilic solid active ingredient-surfactant complex is dissolved or dispersed as a particle having a particle size of 2 nm to 100 nm in the oil phase.

13 . The production method according to claim 10 , wherein in the nonaqueous composition for external use on the skin, the strongly hydrophilic amphiphilic solid active ingredient-surfactant complex is dissolved or dispersed in the oil phase in such a way that the strongly hydrophilic amphiphilic solid active ingredient forms a palisade particle in which the solid active ingredient is distributed in a palisade layer of a molecular film of a surfactant, or forms a mixed micelle particle or a self-assembly comprising a vesicle together with a surfactant.

14 . The production method according to claim 10 , wherein the mass ratio of the surfactant to the strongly hydrophilic amphiphilic solid active ingredient is 2 to 50 times.

15 . The production method according to claim 10 , wherein the strongly hydrophilic amphiphilic solid active ingredient is one or more selected from the group consisting of palmitoyl-L-carnitine, hydroxycitryl palmitate, ascorbyl phosphate palmitate, (ascorbyl/tocopheryl) phosphate, cyclic lysophosphatidic acid, and salts thereof.

16 . The production method according to claim 10 , wherein the surfactant is a nonionic surfactant.

17 . The production method according to claim 10 , wherein the surfactant is one or more selected from the group consisting of glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene castor oil and hardened castor oil.

18 . The production method according to claim 10 , wherein the HLB value of the surfactant is 10 or less.

Assignees

• Chanel Parfums Beaute
• Kyushu Univ Naational Univ Corporation
• Univ Kyushu Nat Univ Corp

Inventors

• Miyamoto Masayoshi
• Oda Yoshihito
• Goto Masahiro

Classifications

• A61K8/0291 Primary

  Micelles · CPC title

• A61K8/044

  Suspensions · CPC title

• A61K2800/413

  Nanosized, i.e. having sizes below 100 nm · CPC title

• A61K8/678

  Tocopherol, i.e. vitamin E · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title