Core-shell structure, preparation, medicine for external application, tape agent and cosmetic product

Patent metadata

Field	Value
Publication number	US-2019117777-A1
Application number	US-201816089309-A
Country	US
Kind code	A1
Filing date	Feb 7, 2018
Priority date	Feb 9, 2017
Publication date	Apr 25, 2019
Grant date	—

Abstract

Provided is a core-shell structure having an excellent immediate effect in transdermal absorption of an active ingredient.
A core-shell structure comprising a core portion containing an active ingredient, and a shell portion containing a surfactant having an HLB value of 4 to 14, the core portion being solid, and the surfactant containing a saturated hydrocarbon group having 7 to 15 carbon atoms or an unsaturated hydrocarbon group having 7 to 17 carbon atoms.

First claim

1 . A core-shell structure comprising:
a core portion containing an active ingredient, and a shell portion containing a surfactant having an HLB value of 4 to 14, the core portion being solid, the surfactant containing a saturated hydrocarbon group having 7 to 15 carbon atoms or an unsaturated hydrocarbon group having 7 to 17 carbon atoms, and the surfactant comprising at least one selected from the group consisting of sorbitan fatty acid esters, glycerin fatty acid esters, propylene glycol fatty acid esters, and fatty acid alkanolamides.

2 . The core-shell structure according to claim 1 ,
wherein the surfactant is a surfactant formed by linking an alcohol with a fatty acid via ester bonding or amide bonding, and the alcohol has a molecular weight m the range of 70 g/mol to 330 g/mol.

3 . (canceled)

4 . The core-shell structure according to claim 1 , wherein the surfactant comprises at least one selected from the group consisting of sorbitan fatty acid esters, glycerin fatty acid esters, and propylene glycol fatty acid esters.

5 . The core-shell structure according to claim 1 , wherein the glycerin fatty acid ester is at least one selected from monoglycerin fatty acid esters, diglycerin fatty acid esters, and triglycerin fatty acid esters.

6 . The core-shell structure according to claim 1 , wherein a mass ratio between the active ingredient and the surfactant (active ingredient:surfactant) is 1:0.5 to 1:100.

7 . The core-shell structure according to claim 1 , wherein the mass ratio between the active ingredient and the surfactant (active ingredient:surfactant) is 1:5 to 1:100.

8 . The core-shell structure according to claim 1 , wherein the mass ratio between the active ingredient and the surfactant (active ingredient:surfactant) is 1:0.5 to 1:5.

9 . The core-shell structure according to claim 1 , wherein the mass ratio between the active ingredient and the surfactant (active ingredient:surfactant) is 1:0.5 to 1:2.

10 . A formulation comprising the core-shell structure according to claim 1 .

11 . An external medicine comprising the core-shell structure according to claim 1 .

12 . A tape preparation comprising the core-shell structure according to claim 1 .

13 . A cosmetic comprising the core-shell structure according to claim 1 .

Assignees

• Sekisui Chemical Co Ltd

Inventors

• Kawamura Daichi
• Akamine Takayuki
• Tone Saori
• Nakamura Yuuta
• Matsumoto Izumi
• Itou Kazushi

Classifications

• A61K47/14 Primary

  Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters · CPC title

• A61K9/06

  Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title

• A61K9/0043

  Nose · CPC title

• A61K9/70

  Web, sheet or filament bases {; Films; Fibres of the matrix type containing drug (hollow drug-filled fibres A61K9/0092)} · CPC title

• A61K8/42

  Amides · CPC title