Molecular machine

Patent metadata

Field	Value
Publication number	US-2020031663-A1
Application number	US-201816500602-A
Country	US
Kind code	A1
Filing date	Apr 6, 2018
Priority date	Apr 6, 2017
Publication date	Jan 30, 2020
Grant date	—

Abstract

A molecular machine comprising a movement part (2) including a first molecular element (4), a second molecular element (5), and a linking element (6) for constraining a relative movement of the first molecular element (4) and the second molecular element (5), and a control part configured to generate an electrical field around the movement part (2), wherein the first molecular element (4) is fixed relative to the control part, wherein the second molecular element (5) is movable relative to the first molecular element (4) in at least one degree of freedom, and wherein the second molecular element (5) is electrically charged such that the second molecular element (5) aligns to said electrical field.

First claim

1 . A molecular machine, comprising
a movement part ( 2 ) including:
a first molecular element ( 4 ),
a second molecular element ( 5 ), and
a linking element ( 6 ) for constraining a relative movement of the first molecular element ( 4 ) and the second molecular element ( 5 ), and
a control part ( 3 ) configured to generate an electrical field around the movement part ( 2 ), wherein the first molecular element ( 4 ) is fixed relative to the control part ( 3 ), wherein the second molecular element ( 5 ) is movable relative to the first molecular element ( 4 ) in at least one degree of freedom, and wherein the second molecular element ( 5 ) is electrically charged such that the second molecular element ( 5 ) aligns to said electrical field.

2 . The molecular machine of claim 1 , wherein the control part ( 3 ) comprises a fluidic channel ( 9 , 10 ), in which the movement part ( 2 ) is provided, wherein the control part ( 3 ) has an electrical device ( 7 , 8 ) that includes electrodes (H) for creating the electrical field, and wherein the electrodes are connected to the fluidic channel ( 9 , 10 ).

3 . The molecular machine of claim 2 , wherein the control part ( 3 ) comprises at least two electrical devices ( 7 , 8 ) and fluidic channels ( 9 , 10 ) with different orientations to create at least two independent overlaying electrical fields.

4 . The molecular machine of claim 2 , wherein the first molecular element ( 4 ) is fixed to the fluidic channel ( 9 , 10 ).

5 . The molecular machine of claim 2 , wherein the electrical device ( 7 , 8 ) includes an isolating element ( 13 ) configured to isolate the electrodes ( 11 ) from the movement part ( 2 ).

6 . The molecular machine of claim 1 wherein the linking element ( 6 ) is part of the first molecular element ( 4 ) or the second molecular element ( 5 ).

7 . The molecular machine of claim L wherein at least one of the first molecular element ( 4 ), the second molecular element ( 5 ), and the linking element ( 6 ) are biomolecules.

8 . The molecular machine of claim 1 , wherein the first molecular element ( 4 ) is a platform, wherein the second molecular element ( 5 ) is a positioning arm, and wherein the linking element ( 6 ) constrains all relative movement of the first molecular element ( 4 ) and the second molecular element ( 5 ) except of a rotation of the second molecular element ( 5 ) within a plane parallel to the first molecular element ( 4 ).

9 . The molecular machine of claim 1 , wherein fluctuations of at least one of the first molecular element ( 4 ) and the second molecular element ( 5 ) due to diffusion are within a tolerance of at most 10 nm.

10 . The molecular machine of claim 1 , wherein any dimension of the first molecular element ( 4 ) and the second molecular element ( 5 ) is less than 1000 nm.

11 . The molecular machine of claim L wherein the first molecular element ( 4 ) is made from a crossed two-layer scaffold routing, in which a top layer is rotated with respect to a bottom layer by an angle between 80° and 100°.

12 . The molecular machine of claim 1 , wherein the second molecular element ( 5 ) is made from a DNA six-helix bundle.

13 . The molecular machine of claim 1 , wherein the linking element ( 6 ) is created by two adjacent scaffold crossovers with three and four unpaired bases.

14 . The molecular machine of claim 1 , wherein the second molecular element ( 5 ) is adapted to transport inorganic nanoparticles.

15 . The molecular machine of claim 3 , wherein the fluidic channels ( 9 , 10 ) are arranged to intersect at an intersection area ( 12 ), and the movement part ( 2 ) is placed at the intersection area ( 12 ).

16 . The molecular machine of claim 7 , wherein at least one of the first molecular element ( 4 ), the second molecular element ( 5 ), and the linking element ( 6 ), are made of at least one of DNA, DNA-origami, RNA, protein, and artificial charged supramolecular structures.

17 . The molecular machine of claim 9 , wherein fluctuations of at least one of the first molecular element ( 4 ) and the second molecular element ( 5 ) due to diffusion are within a tolerance of at most 1 nm.

18 . The molecular machine of claim 9 , wherein fluctuations of at least one of the first molecular element ( 4 ) and the second molecular element ( 5 ) due to diffusion are within a tolerance of at most 0.5 nm.

19 . The molecular machine of claim 11 , wherein the top layer is rotated with respect to a bottom layer by an angle of 90°.

Assignees

• Univ Muenchen Tech

Inventors

• Kopperger Enzo
• List Jonathan
• Simmel Friedrich C

Classifications

• B82B1/002 Primary

  Devices comprising flexible or deformable elements · CPC title

• B81B2201/034

  Electrical rotating micromachines · CPC title

• B82B1/003 Primary

  Devices comprising elements which are movable in relation to each other, e.g. slidable or rotatable · CPC title

• C12Q1/68

  involving nucleic acids · CPC title

• B81B5/00

  Devices comprising elements which are movable in relation to each other, e.g. comprising slidable or rotatable elements · CPC title