Biocompatible in situ hydrogel
US-9844597-B2 · Dec 19, 2017 · US
US2019201558A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2019201558-A1 |
| Application number | US-201916296795-A |
| Country | US |
| Kind code | A1 |
| Filing date | Mar 8, 2019 |
| Priority date | Dec 15, 2009 |
| Publication date | Jul 4, 2019 |
| Grant date | — |
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Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.
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1 . A method for radiation therapy comprising introducing a hydrogel spacer at a site between a first tissue location and a second tissue location to increase a distance between the first tissue location and the second tissue location, with site being chosen to decrease radiation at the first tissue when the second tissue receives a dose of therapeutic radiation, wherein introducing the hydrogel spacer comprises placing one or more flowable synthetic precursors at the site that undergo a covalent crosslinking reaction to make, at the site, a covalently-crosslinked biodegradable hydrogel implant that has a covalently attached radiopaque agent. 2 . A method of making a space-occupying implant in a tissue, comprising injecting a tissue site with one or more flowable synthetic precursors in aqueous medium that undergo a covalent cross-linking reaction to make, in the site, a covalently-crosslinked biodegradable hydrogel implant that has a covalently attached radiopaque iodine agent.
Antineoplastic agents · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives · CPC title
Materials at least partially resorbable by the body · CPC title
Hydrogels or hydrocolloids · CPC title
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